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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Real-Time Biosensor For The Assessment Of Nanotoxicity And Cancer Electrotherapy, Evangelia Hondroulis Nov 2013

Real-Time Biosensor For The Assessment Of Nanotoxicity And Cancer Electrotherapy, Evangelia Hondroulis

FIU Electronic Theses and Dissertations

Knowledge of cell electronics has led to their integration to medicine either by physically interfacing electronic devices with biological systems or by using electronics for both detection and characterization of biological materials. In this dissertation, an electrical impedance sensor (EIS) was used to measure the electrode surface impedance changes from cell samples of human and environmental toxicity of nanoscale materials in 2D and 3D cell culture models. The impedimetric response of human lung fibroblasts and rainbow trout gill epithelial cells when exposed to various nanomaterials was tested to determine their kinetic effects towards the cells and to demonstrate the biosensor ...


Implantable Biosensors For Physiologic Status Monitoring During Hemorrhage, Christian Kotanen Aug 2013

Implantable Biosensors For Physiologic Status Monitoring During Hemorrhage, Christian Kotanen

All Dissertations

Trauma diagnostics and management are major aims of research for implantable amperometric enzyme biosensor technology. Biosensors are capable of monitoring metabolic variables in a minimally invasive manner and have great potential to augment current wireless vital sign monitoring technologies in order to make a more robust physiologic status monitoring platform. The dual responsive Electrochemical Cell-on-a-Chip Microdisc Electrode Array (ECC MDEA 5037) is a recently developed electrochemical transducer for use in a wireless, implantable biosensor system for the continuous measurement of interstitial glucose and lactate. Hyperglycemia arising from insulin resistance and hyperlactatemia arising from anaerobic metabolism both occur following trauma and ...


Parallel Recording Of Neurotransmitters Release From Chromaffin Cells Using A 10 X 10 Cmos Ic Potentiostat Array With On-Chip Working Electrodes, Brian Kim, Adam Herbst, Sung Kim, Bradley Minch, Manfred Lindau Feb 2013

Parallel Recording Of Neurotransmitters Release From Chromaffin Cells Using A 10 X 10 Cmos Ic Potentiostat Array With On-Chip Working Electrodes, Brian Kim, Adam Herbst, Sung Kim, Bradley Minch, Manfred Lindau

Bradley Minch

Neurotransmitter release is modulated by many drugs and molecular manipulations. We present an active CMOS-based electrochemical biosensor array with high throughput capability (100 electrodes) for on-chip amperometric measurement of neurotransmitter release. The high-throughput of the biosensor array will accelerate the data collection needed to determine statistical significance of changes produced under varying conditions, from several weeks to a few hours. The biosensor is designed and fabricated using a combination of CMOS integrated circuit (IC) technology and a photolithography process to incorporate platinum working electrodes on-chip. We demonstrate the operation of an electrode array with integrated high-gain potentiostats and output time-division ...


Myoglobin Detection On Sic: Immunosensor Development For Myocardial Infarction, Alexandra Oliveros Villalba Jan 2013

Myoglobin Detection On Sic: Immunosensor Development For Myocardial Infarction, Alexandra Oliveros Villalba

Graduate Theses and Dissertations

Silicon carbide (SiC) has been around for more than 100 years as an industrial material and has found wide and varied applications because of its unique electrical and thermal properties. In recent years there has been increased attention on SiC as a viable material for biomedical applications. Among these applications are those where SiC is used as a substrate material for biosensors and biotransducers, taking advantage of its surface chemical, tribological and electrical properties.

In this work we have used the proven bio- and hema-compatibility of SiC to develop a viable biorecognition interface using SiC as the substrate material for ...


Vapor-Liquid-Solid(Vls) Grown Silica (Siox) Nanowires As The Interface For Biorecognition Molecules In Biosensors, Eduardo Murphy-Pérez Jan 2013

Vapor-Liquid-Solid(Vls) Grown Silica (Siox) Nanowires As The Interface For Biorecognition Molecules In Biosensors, Eduardo Murphy-Pérez

Graduate Theses and Dissertations

SiOx nanowires grown through the VLS mechanism were electrophoretically deposited on top of Au electrodes. GOx was immobilized using APTES and the EDC-NHS chemistry. Cyclic Voltammetry was used as the method to characterize the electrodes through their processing steps, and CV was also used to detect glucose in a PBS based solution. Ferro-Ferri Cyanide couple was used as the mediator.