Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Biomedical Engineering and Bioengineering
Synthesis And Characterization Of Biodegradable Poly(Vinyl Esters) With Hdac Inhibitory Activity, Kyle Lawrence Horton
Synthesis And Characterization Of Biodegradable Poly(Vinyl Esters) With Hdac Inhibitory Activity, Kyle Lawrence Horton
Wayne State University Theses
HDAC inhibitors are known to have anti-inflammatory properties. HDAC inhibitors are used in combination with Oct4 to generate induced pluripotent stem cells. I hypothesized that polyesters based on simple aliphatic HDAC inhibitors like valproic acid (VPA) and phenylbutyric acid (PBA) can serve as alternatives to existing polyester biomaterials with improved anti-inflammatory properties and as scaffolds for generation of iPSCs when used in combination with layer-by-layer thin films delivering reprogramming transcription factors. Vinyl ester of phenylbutyric acid (VEPA) and vinyl ester of valproic acid (VEVA) were synthesized from their carboxylic acid precursors using an iridium complex catalyst at yields as high …
Investigation Of Physiochemical Properties Of A Novel Gradient Calcium Polyphosphate Bone Scaffold And Its Influence On Cellular Behavior, Liang Chen
Wayne State University Theses
A good designed bone scaffold is crucial to bone tissue engineering. We have developed and characterized a novel gradient bone scaffold by combination of Calcium Polyphosphate (CPP) with different size of porogen (stearic acids). Compared with homogenous scaffold, the gradient bone scaffold with different pore size and porosity can better mimic natural bone structure. Directly perfusion flow bioreactor was developed. This 3D dynamic cell culture was better mimic the physiological condition for cell growth. It was beneficial to nutrition and oxygen delivery throughout the whole scaffold and was able to form shear stress. We wanted to investigate the effect of …
Compressed Sensing And Joint Acquisition Techniques In Mri, Rouhollah Hamtaei
Compressed Sensing And Joint Acquisition Techniques In Mri, Rouhollah Hamtaei
Wayne State University Theses
The relatively long scan times in Magnetic Resonance Imaging (MRI) limits some clinical applications and the ability to collect more information in a reasonable period of time. Practically, 3D imaging requires longer acquisitions which can lead to a reduction in image quality due to motion artifacts, patient discomfort, increased costs to the healthcare system and loss of profit to the imaging center. The emphasis in reducing scan time has been to a large degree through using limited k-space data acquisition and special reconstruction techniques. Among these approaches are data extrapolation methods such as "constrained reconstruction" techniques, data interpolation methods such …