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Biomedical Engineering and Bioengineering Commons™

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2013

Conference

Biological Engineering

Articles 1 - 7 of 7

Full-Text Articles in Biomedical Engineering and Bioengineering

Bicistronic Design For Precise And Reliable Gene Expression, Nidhi N. Menon, Jenna Rickus Oct 2013

Bicistronic Design For Precise And Reliable Gene Expression, Nidhi N. Menon, Jenna Rickus

The Summer Undergraduate Research Fellowship (SURF) Symposium

Despite having progressed extensively in the field of synthetic biology in terms of DNA synthesis, analysis and transplanting, we still cannot reliably, quantitatively measure expression of new genetic constructs. We engineered a biobrick compatible expression cassette to control transcription and translation initiation which can be reused in new genetic contexts. Previous research has shown that the Bicistronic design have much lesser variations in expression with varying genes of interest as compared to the regular monocistronic design.(Mutalik, Endy, Guimaraes, Cambray, Lam, Juul, Tran & Paull, 2013) The Bicistronic design(BCD) consists of two Shine-Dalgarno sequences in its translation element which when combined …

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Determination Of Master Compliance Curve For Extruded Semolina Pasta, Laura E. Emery, Martin Okos Oct 2013

Determination Of Master Compliance Curve For Extruded Semolina Pasta, Laura E. Emery, Martin Okos

The Summer Undergraduate Research Fellowship (SURF) Symposium

The dependence of the rate of relaxation of semolina pasta on moisture content and temperature and how it affects shrinkage during drying has not yet been determined. The purpose of this research was to develop an equation that relates moisture content and temperature in order to obtain a master curve for creep of the product. When found, this equation could help to optimize the drying process and increase the quality of the final pasta product. Semolina flour mixed with water and propionic acid to create a 35% wet basis product was extruded on a C.W. Brabender 2523 to obtain a …

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Artificial Yeast Polarization Controlled By Chemical Gradient, James K. Nolan, Bernard Tao Oct 2013

Artificial Yeast Polarization Controlled By Chemical Gradient, James K. Nolan, Bernard Tao

The Summer Undergraduate Research Fellowship (SURF) Symposium

Engineering synthetic multicellular systems will lead to new synthetic biology technological platforms, inform developmental biology through recapitulation of natural systems and possibly unveil novel morphologies with practical applications not before reached throughout natural history (Maharbiz, 2012). Creating an exogenous molecular circuit that will polarize unicellular cells into “apical” and “basal” domains relative to a substrate plane would fulfill a missing component towards fully multicellular synthetic cellular communities (Maharbiz, 2012). To this end, a PIP3 polarization network previously designed by Chau and associates (Chau, Walter, Gerardin, Tang, Lim 2012) was coupled to the specific activation by niacin of a recombinant …

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Image Skeletal Muscle Progenitors In Situ To Investigate How The Ecm Composition Regulates Musculoskeletal Assembly, Andrew L. Schilb, Sarah Calve Oct 2013

Image Skeletal Muscle Progenitors In Situ To Investigate How The Ecm Composition Regulates Musculoskeletal Assembly, Andrew L. Schilb, Sarah Calve

The Summer Undergraduate Research Fellowship (SURF) Symposium

Regenerative medicine has difficulty with the human body’s inability to functionally repair tissues lost as a result of disease or serious accident. Through tissue engineering, there has been development of various scaffolding with the purpose of enhancing skeletal muscle regrowth and functionality. The scaffolds are typically constructed from artificial polymers or decellularized extracellular matrix (ECM) that mimics adult tissue. These standardized scaffolds are hindered though by the host since tissue engineers have not taken into account of how the composition musculoskeletal ECM during tissue repair is dramatically different than that of a homeostatic adult. Now green fluorescent protein positive (GFP+) …

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Adhesive Elastomeric Proteins, Haefa Mansour, Julie Liu Oct 2013

Adhesive Elastomeric Proteins, Haefa Mansour, Julie Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Sutures and staples commonly used to close surgical wounds tend to be much stiffer than the surrounding tissue, often resulting in external tissue damage. Surgical adhesives provide a promising alternative to these sutures and staples. Ideal surgical adhesives are biocompatible, able to set well and remain sticky in moist conditions, possess strong adhesive and cohesive properties, and exhibit mechanical properties that mimic those of the surrounding tissue. Unfortunately, the adhesives available today are unable to satisfactorily meet all of these criteria. We are utilizing protein engineering techniques to design, create, and test a new surgical adhesive that combines the adhesive …

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Computational Capabilities Of Leaky Integrate-And-Fire Neural Networks For Liquid State Machines, Amin Almassian, Christof Teuscher May 2013

Computational Capabilities Of Leaky Integrate-And-Fire Neural Networks For Liquid State Machines, Amin Almassian, Christof Teuscher

Student Research Symposium

We analyze the computational capability of Leaky Integrate-and-Fire (LIF) Neural Networks used as a reservoir (liquid) in the framework of Liquid State Machines (LSM). Maass et. al. investigated LIF neurons in LSM and their results showed that they are capable of noise-robust, parallel, and real-time computation. However, it still remains an open question how the network topology affects the computational capability of a reservoir. To address that question, we investigate the performance of the reservoir as a function of the average reservoir connectivity. We also show that the dynamics of the LIF reservoir is sensitive to changes in the average …

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Elucidating Role Of Heart Valve Cells In The Aortic Valve Calcification, Mary Katherine Bailey, Adithi Amarnath Mar 2013

Elucidating Role Of Heart Valve Cells In The Aortic Valve Calcification, Mary Katherine Bailey, Adithi Amarnath

EURēCA: Exhibition of Undergraduate Research and Creative Achievement

No abstract provided.

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