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Biomedical Engineering and Bioengineering Commons

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2013

The Summer Undergraduate Research Fellowship (SURF) Symposium

Aneurysms

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Full-Text Articles in Biomedical Engineering and Bioengineering

Visualization Of Complex Flow Patterns In Angiotensin Ii-Induced Dissecting Murine Abdominal Aortic Aneurysms With High Frequency Ultrasound, Hilary D. Schroeder, Alexa A. Yrineo, Amy E. Bogucki, Craig J. Goergen Oct 2013

Visualization Of Complex Flow Patterns In Angiotensin Ii-Induced Dissecting Murine Abdominal Aortic Aneurysms With High Frequency Ultrasound, Hilary D. Schroeder, Alexa A. Yrineo, Amy E. Bogucki, Craig J. Goergen

The Summer Undergraduate Research Fellowship (SURF) Symposium

Abdominal aortic aneurysm (AAA) rupture is a common cause of mortality in the United States. Current treatments are only employed once the risk of rupture outweighs the risks associated with surgery. Murine models have been developed to characterize AAA pathogenesis in the hope that new treatments will be developed. For this study, angiotensin II (AngII) was infused subcutaneously into apolipoprotein E-deficient (ApoE-/-) mice using an osmotic mini-pump over 28 days. ApoE-/- mice (16-week-old, 3 females, 2 males) were imaged using a VisualSonics Vevo 2100 high frequency ultrasound before pump implantation and 3, 7, 14, 21, and 27 days following implantation ...