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Biomedical Engineering and Bioengineering Commons

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Articles 1 - 6 of 6

Full-Text Articles in Biomedical Engineering and Bioengineering

Ultrasound Assisted Cavitation Around Pulsed Laser Illuminated Nanoparticles, Hengyi Ju Jan 2013

Ultrasound Assisted Cavitation Around Pulsed Laser Illuminated Nanoparticles, Hengyi Ju

Mechanical Engineering Graduate Theses & Dissertations

The laser generation of vapor bubbles around plasmonic nanoparticles can be enhanced through the application of an ultrasound field; a technique referred to as photoacoustic cavitation. The combination of light and sound allows for bubble formation at lower laser fluence and peak negative ultrasound pressure than can be achieved using either modality alone. The growth and collapse of these bubbles leads to local mechanical disruption and acoustic emission, and can potentially be used to induce and monitor tissue therapy. The objective of this thesis is to understand the physics of nanoparticle-mediated photoacoustic cavitation, develop approaches to minimize the cavitation threshold ...


The Effects Of Matrix Elasticity, Composition, And Exogenous Growth Factors On The Vascular Differentiation Of Mesenchymal Stem Cells, Kathryn Anne Wingate Jan 2013

The Effects Of Matrix Elasticity, Composition, And Exogenous Growth Factors On The Vascular Differentiation Of Mesenchymal Stem Cells, Kathryn Anne Wingate

Mechanical Engineering Graduate Theses & Dissertations

Cardiovascular diseases are the leading cause of death in the western world. Regeneration of functional vascular tissue remains a critical barrier to successful treatment of these diseases. Attempts to produce functional vascular tissue with autogenous vascular cells have limited success due to the need for invasive surgery. Mesenchymal stem cells (MSCs) are a powerful cellular alternative for vascular regeneration as they are easily obtainable, multipotent, and thrombo-resistant. Currently, the mechanisms that drive MSC differentiation to healthy or diseased vascular phenotypes are not well understood. There is a critical need to define the factors in the cellular microenvironment that guide MSC ...


Bone Morphology And Mechanical Properties In Murine Models Of Chronic Kidney Disease, Andrew C. Cureton Jan 2013

Bone Morphology And Mechanical Properties In Murine Models Of Chronic Kidney Disease, Andrew C. Cureton

Mechanical Engineering Graduate Theses & Dissertations

The aim of this thesis is to investigate the changes in the bone tissue of mice that occur as a result of Chronic Kidney Disease (CKD). Due to the disruptions in mineral homeostasis and metabolism that result from loss of renal function, individuals with CKD are at a higher risk of bone fracture. In order to study the relationship between CKD and bone responses two surgical models of CKD are used herein: uninephrectomy (UNx) and 5/6 nephrectomy (5/6Nx). In general, surgically induced CKD was accompanied with a decrease in bone quality as measured by &muCT morphological analysis, mechanical ...


Design, Development, And Verification Of An Automated Pain Measurement Device, Morgan L. Hill Jan 2013

Design, Development, And Verification Of An Automated Pain Measurement Device, Morgan L. Hill

Mechanical Engineering Graduate Theses & Dissertations

The focus of this study is the redesign, development, fabrication, and initial evaluation of an automated pain measurement device. The redesign will focus on improving the original Computer Controlled Pressure Algometer, designed by Zimkowski in 2010. Pain measurement is very difficult to accurately accomplish, and current methods are limited to subjective techniques such as pain rating scales and handheld algometry. These subjective methods of pain measurement have many shortcomings that render them inadequate at reliably assessing an individual's pain. Large variability has been shown with these testing methods, which can be prone to error due to test administrator, environmental ...


Migrating Motor Complex Force Sensor: Design, Fabrication, And Clinical In Vivo Measurements, Matthew Michael Francisco Jan 2013

Migrating Motor Complex Force Sensor: Design, Fabrication, And Clinical In Vivo Measurements, Matthew Michael Francisco

Mechanical Engineering Graduate Theses & Dissertations

In a continued effort to explore the human digestive tract for diagnostic and therapeutic purposes in a minimally invasive fashion, researchers are developing a new type of medical device: the robotic capsule endoscope (RCE). This small, untethered instrument is actively controlled by the physician and combines the functionality of traditional, flexible endoscopy with the versatility of a swallowable device. The narrow, convoluted geometry and active peristaltic forces within the small intestine represent the most challenging environment within the human gastrointestinal (GI) tract for a RCE to operate. A critical design parameter is the active peristaltic forces generated by the migrating ...


Thermal Tissue Fusion Of Arteries: Methods, Mechanisms, & Mechanics, James David Cezo Jan 2013

Thermal Tissue Fusion Of Arteries: Methods, Mechanisms, & Mechanics, James David Cezo

Mechanical Engineering Graduate Theses & Dissertations

Tissue fusion is a method of joining biological tissues using heat and pressure. Tissue fusion has been used effectively for the ligation of blood vessels during surgery, which is performed by clamping the blood vessel closed and then applying heat to the tissue. During tissue fusion, the structural proteins in the tissue denature, water is vaporized, and a bond is formed between the tissues. The mechanics and mechanisms of the tissue fusion bond are still unknown and to this end, experiments were developed to elucidate the crucial parameters necessary to fuse tissue and measure the mechanical response of the bond ...