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Full-Text Articles in Biomedical Engineering and Bioengineering

Pulsatile Flow Does Not Improve Efficacy In Ex Vivo Lung Perfusion., Keith A. Zoeller Dec 2013

Pulsatile Flow Does Not Improve Efficacy In Ex Vivo Lung Perfusion., Keith A. Zoeller

Electronic Theses and Dissertations

Introduction Ex vivo lung perfusion (EVLP) has the potential to increase the donor pool for lung transplantation by facilitating extended evaluation of marginal organs. Current methodology employs continuous flow pumps for perfusion. In vivo, continuous flow has been shown to increase pulmonary vascular resistance (PVR). Thus, pulsatile flow EVLP may reduce PVR and improve organ preservation by providing physiologic flow morphology. Methods Lung blocks harvested from male, Yorkshire pigs were allocated into continuous (CF, n=3) and pulsatile flow (PF, n=4) groups. Lungs were ventilated at 4-5 mL/kg, 30% FiO2 and perfused with an acellular, albumin-based solution corrected ...


Development Of A Computational Approach To Assess Hip Fracture And Repair: Considerations Of Intersubject And Surgical Alignment Variability, Azhar Ali Nov 2013

Development Of A Computational Approach To Assess Hip Fracture And Repair: Considerations Of Intersubject And Surgical Alignment Variability, Azhar Ali

Electronic Theses and Dissertations

Hip fracture remains a major public health concern due to the significant number of occurrences and mortality rates. Intertrochanteric fractures are the most common type of fracture and are typically caused by a fall. Intramedullary osteosynthesis is a common surgical practice to repair intertrochanteric fractures, but revisions are often required. The work presented in this thesis aims to improve the realism and fidelity of computational models of hip fracture, which can be an effective alternative to costly and labor-intensive clinical in-vivo and experimental in-vitro testing. Intersubject variability is inherently present in anatomy and material relations. Statistical shape and intensity models ...


Computational Biomechanical Modeling Of The Human Knee During Kneeling, Tariq R. Abo-Alhol Aug 2013

Computational Biomechanical Modeling Of The Human Knee During Kneeling, Tariq R. Abo-Alhol

Electronic Theses and Dissertations

Total knee replacement benefits patients who suffer from severe knee pain or joint stiffness and other joint related illnesses that limit everyday activities. There has been an increase in the number of procedures performed each year and a need to evaluate the performance of these implants during specialized activities such as kneeling. Most computational studies lack insight into inter-patient variability and the results do not apply to large population. This study developed: (1) three-dimensional explicit finite element (FE) models to investigate natural and implanted knee joint kinematics and bone strain and (2) a platform to enable population-based evaluation by combining ...


Study Of Immobilizing Cadmium Selenide Quantum Dots In Selected Polymers For Application In Peroxyoxalate Chemiluminescence Flow Injection Analysis, Christopher S. Moore May 2013

Study Of Immobilizing Cadmium Selenide Quantum Dots In Selected Polymers For Application In Peroxyoxalate Chemiluminescence Flow Injection Analysis, Christopher S. Moore

Electronic Theses and Dissertations

Two batches of CdSe QDs with different sizes were synthesized for immobilizing in polyisoprene (PI), polymethylmethacrylate (PMMA), and low-density polyethylene (LDPE). The combinations of QDs and polymer substrates were evaluated for their analytical fit-for-use in applicable immunoassays. Hydrogen peroxide standards were injected into the flow injection analyzer (FIA) constructed to simulate enzyme-generated hydrogen peroxide reacting with bis-(2,4,6-trichlorophenyl) oxalate.

Linear correlations between hydrogen peroxide and chemilumenscent intensities yielded regression values greater than 0.9750 for hydrogen peroxide concentrations between 1.0 x 10-4 M and 1.0 x 10-1 M. The developed technique’s LOD was ...


Modeling Hrtf For Sound Localization In Normal Listeners And Bilateral Cochlear Implant Users, Douglas A. Miller Jan 2013

Modeling Hrtf For Sound Localization In Normal Listeners And Bilateral Cochlear Implant Users, Douglas A. Miller

Electronic Theses and Dissertations

Mathematical models can be very useful for understanding complicated systems and for testing algorithms through simulation that would be difficult or expensive to implement. This dissertation presents a model that attempts to simulate the sound localization performance of persons using bilateral cochlear implants. The expectation is that this model could prove to be a useful tool in developing new signal processing algorithms for neural encoding strategies.

The head related transfer function (HRTF) is a critical component of this model, and in the ideal case, provides the base characteristics of head shadow, torso and pinna effects. This defines the temporal, intensity ...


Representing Intersubject Variability With A Statistical Shape And Alignment Model Of The Knee, Chandreshwar Rao Jan 2013

Representing Intersubject Variability With A Statistical Shape And Alignment Model Of The Knee, Chandreshwar Rao

Electronic Theses and Dissertations

Prior statistical shape models have not considered multiple structures in the knee joint to characterize anatomic variation which are required to investigate joint mechanics further for the successful knee replacement. Accordingly, the study's objective was to develop statistical shape and alignment model (SSAM) to capture intersubject variability and demonstrate the ability to generate realistic instances for use in finite element analysis (FEA). SSAM described the variability in the training set of 20 subjects with a series of modes of variation obtained by performing principal component analysis (PCA). PCA produced modes of variation with the first 3 modes representing 70 ...