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Full-Text Articles in Biomedical Engineering and Bioengineering

A Novel Resistance Exercise Machine For Use In A Lower Body Negative Pressure Box To Counteract The Effects Of Weightlessness, Christine M. Dailey Jan 2013

A Novel Resistance Exercise Machine For Use In A Lower Body Negative Pressure Box To Counteract The Effects Of Weightlessness, Christine M. Dailey

Dissertations and Theses

Physiological deconditioning is a critical problem in space, especially during long-term missions. Resistance exercise coupled with lower body negative pressure (LBNP) has been shown to be effective in counteracting some of the deconditioning related problems. This thesis describes the development of a compact and effective resistance exercise machine that works within an existing environmentally controlled LBNP Box and is designed to simulate both exercise and sitting, to prevent microgravity-induced deconditioning by simulating physiological and biomechanical features of upright exercise and daily activities. Theoretical calculations are carried out to determine whether kinematics, musculoskeletal loadings, and metabolic rate during supine exercise within ...


A Novel Biomaterial Enables Chemotactic Study Of Motile Central Nervous System-Derived Tumor Cells, Tanya Singh Jan 2013

A Novel Biomaterial Enables Chemotactic Study Of Motile Central Nervous System-Derived Tumor Cells, Tanya Singh

Dissertations and Theses

"The local cell microenvironment plays an important role in maintaining the dynamics of the extracellular matrix (ECM) and the cell-ECM relationship. ECM is a complex network of macromolecules with distinct mechanical and biochemical characteristics [1]. The multifaceted interactions that occur between cells and the ECM are crucial to the regulation of processes that maintain homeostasis. These mechanisms are often deregulated during cancer onset and progression, which cause the ECM to become highly disorganized, alter the cell-matrix interactions, and promote increased hypervascularity and metastasis as these components are indicative of cancer progression. Medulloblastoma (MB) is one of the most common, malignant ...


Finite Element Study Of Transcranial Direct Current Stimulation: Customization Of Models And Montages, Dennis Q. Truong Jan 2013

Finite Element Study Of Transcranial Direct Current Stimulation: Customization Of Models And Montages, Dennis Q. Truong

Dissertations and Theses

Transcranial Direct Current Stimulation (tDCS) is a non-invasive neuromodulation technique that applies low amplitude current via electrodes placed on the scalp. Rather than directly eliciting a neuronal response, tDCS is believed to modulate excitability – encouraging or suppressing activity in regions of the brain depending on the polarity of stimulation. The particular application of tDCS is often determined by the electrode configuration and intensity of stimulation. MRI-derived finite element models have been developed to analyze the effect of these parameters allowing novel electrode configurations to be tested in subject specific models. By creating a subject specific model of an obese subject ...


Transport Pathway Across Hcaecs Uncer Convective Condtitions And The Role Of Apoptosis In Ldl Transport Through Hcaecs, Janpen Phupeerasupong Jan 2013

Transport Pathway Across Hcaecs Uncer Convective Condtitions And The Role Of Apoptosis In Ldl Transport Through Hcaecs, Janpen Phupeerasupong

Dissertations and Theses

No abstract provided.


Application Of Computational Fluid Dynamics As A Simulation-Based Design Guide In A Microfluidic 3d Living Cell Array (3d Lca) Device, A.H. Rezwanuddin Ahmed Jan 2013

Application Of Computational Fluid Dynamics As A Simulation-Based Design Guide In A Microfluidic 3d Living Cell Array (3d Lca) Device, A.H. Rezwanuddin Ahmed

Dissertations and Theses

The use of computational fluid dynamics (CFD) as a tool in the aerodynamics and oil industry provides a reinforcement to efficiency in the design of aircrafts or for understanding the flow through pipes. A similar approach can be taken towards microfluidics, where traditionally devices have been designed based on experience or physiological replication, and a CFD simulation is shown post-manufacture to show the flow and diffusion patterns present. In this study, a reverse approach is suggested, by designing the device first in CFD and perform simulations on variations of alterable parameters to get insight on how the changing parameters affect ...


Effect Of Rolling On Viscoelastic Fluids Using A Novel Testing Device, Aswini Mangadu Jan 2013

Effect Of Rolling On Viscoelastic Fluids Using A Novel Testing Device, Aswini Mangadu

Dissertations and Theses

The purpose of this research thesis project was to develop a mechanical testing device that could enable us to load articular cartilage with a rolling/sliding motion. This novel device was then used to observe the effect of a rolling motion on the fluid film thickness of different lubricants (motor oil, synovial fluid and Hyaluronic Acid (HA)) to varying loads (1kg, 2,kg, 3kg and 4kg) and speeds (10, 25, 48 and 91 mm/s) applied on the sample fluids for 10 cycles. We were able to examine the effect of different speeds within each load for each of the ...


A Novel Visual Stimulation Paradigm: Exploiting Individual Primary Visual Cortex Geometry To Boost Steady State Visual Evoked Potentials (Ssvep), Marta Isabel Vanegas Arroyave Jan 2013

A Novel Visual Stimulation Paradigm: Exploiting Individual Primary Visual Cortex Geometry To Boost Steady State Visual Evoked Potentials (Ssvep), Marta Isabel Vanegas Arroyave

Dissertations and Theses

The steady-state visual evoked potential (SSVEP) is an electroencephalographic response to flickering stimuli generated in significant part by activity in primary visual cortex (V1). SSVEP signal-to-noise ratio is generally low for stimuli that are located in the visual periphery, at frequencies higher than 20 Hz, or at low contrast. Because of the typical "cruciform" geometry of V1, large stimuli tend to excite neighboring cortical regions of opposite orientation, likely resulting in electric field cancellation. In Study 1, we explored ways to exploit V1 geometry in order to boost scalp SSVEP amplitude via oscillatory summation, by manipulating flicker-phase offsets among angular ...


Design, Product Development And Risk Assessment Of Tin (Sn) Ring Electrodes As A Substitute To Silver-Silver Chloride (Ag Agci) Ring Electrodes For High Definition Transcranial Direct Current Stimulation (Hd-Tdcs), Linford Leitch Jan 2013

Design, Product Development And Risk Assessment Of Tin (Sn) Ring Electrodes As A Substitute To Silver-Silver Chloride (Ag Agci) Ring Electrodes For High Definition Transcranial Direct Current Stimulation (Hd-Tdcs), Linford Leitch

Dissertations and Theses

The objective of this research thesis is to test the viability of Tin (Sn) ring electrodes as an inexpensive alternative to sintered Silver-Silver Chloride (Ag|AgCl) ring electrodes for High Definition – transcranial Direct Current Stimulation (HD-tDCS). Throughout our initial bench top testing of tin electrodes in combination with a ‘conductive electrode gel’, the passing of a 2mA direct current on agar block showed the formation of white cloud around the anode electrode and a cluster of air bubbles on the cathode. The analysis of pertinent literature indicates that the white milky substance produced during the stimulation at the anode is ...


Design, Implementation, And Performance Study Of An Open Source Eye-Control System To Pilot A Parrot Ar.Drone Quadrocopter, John M. Ettikkalayil Jan 2013

Design, Implementation, And Performance Study Of An Open Source Eye-Control System To Pilot A Parrot Ar.Drone Quadrocopter, John M. Ettikkalayil

Dissertations and Theses

Natural user interface is a fairly new concept in the field of human-computer interaction. It is the idea of using every day natural human behaviors and actions to control a device. An example of a natural user interface is touch control technology in smartphones, tablets, and new laptops. The interaction is more direct when compared to artificial input devices like a keyboard and mouse. Though natural user interface devices might not perform as well as standard input devices for certain applications, for other applications they are now the de facto standard. A new user interface that is poised to be ...