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Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

2013

Dissertations (2009 -)

Advanced glycation end-products, ALT-711, neointimal hyperplasia, stent, type 2 diabetes mellitus

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Vascular Changes In Type 2 Diabetes Mellitus: Application To Restenosis After Stenting, Hongfeng Wang Jan 2013

Vascular Changes In Type 2 Diabetes Mellitus: Application To Restenosis After Stenting, Hongfeng Wang

Dissertations (2009 -)

Stents used to decrease cardiovascular risk in patients with type 2 diabetes mellitus (T2DM) are prone to increased rates of restenosis. The mechanisms are incompletely elucidated, but low wall shear stress (WSS) and altered intracellular signaling likely contribute. We tested the hypothesis that neointimal hyperplasia (NH) after bare-metal stenting is due to vascular remodeling (enhanced formation of advanced glycation end-products (AGEs), increased downstream vascular resistance (DVR), and decreased WSS), and that decreasing AGEs with ALT-711 (Alagebrium) mitigates this response.

Stents were implanted into the abdominal aorta of Zucker lean (ZL), obese (ZO), and diabetic (ZD) rats. After 21 days, the ...