Biomedical Engineering and Bioengineering Commons^™

Safety And Efficacy Of Ranolazine For The Treatment Of Chronic Angina Pectoris, Mohammed Aldakkak, David F. Stowe, Amadou K.S. Camara

Biomedical Engineering Faculty Research and Publications

Coronary heart disease is a global malady and it is the leading cause of death in the United States. Chronic stable angina is the most common manifestation of coronary heart disease and it results from the imbalance between myocardial oxygen supply and demand due to reduction in coronary blood flow. Therefore, in addition to lifestyle changes, commonly used pharmaceutical treatments for angina (nitrates, ß-blockers, Ca2+ channel blockers) are aimed at increasing blood flow or decreasing O2 demand. However, patients may continue to experience symptoms of angina. Ranolazine is a relatively new drug with anti-anginal and anti-arrhythmic effects. Its anti-anginal mechanism …