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Full-Text Articles in Biomedical Engineering and Bioengineering
Mechanical Properties Of Hydrated Acoustically Sensitive Alginate-Based Microcapsules Confined In A Microfluidic Device As A Function Of Size And Composition, Maryam Mobed-Miremadi, Mallika Keralapura, Tiffany Fong, Rogel Camba
Mechanical Properties Of Hydrated Acoustically Sensitive Alginate-Based Microcapsules Confined In A Microfluidic Device As A Function Of Size And Composition, Maryam Mobed-Miremadi, Mallika Keralapura, Tiffany Fong, Rogel Camba
Bioengineering
Understanding the mechanical properties of alginate-based microcapsules according to size and chemical composition allows researchers to zero in on the treatment and methods required to engineer optimized implantable alginate-based artificial cells for chemotherapy. Cross-linked medium viscosity alginate capsules ranging from 1.1% (w/v)-1.8% (w/v) in composition and 200 μm-1200 μm in size, encapsulating ultrasound contrast agents and blue dextran were compressed within a 40 μm high polydimethylsiloxane microfluidic device and subsequently examined using 2D microscopy for strain deformation aimed at the calculation of poisson ratios and volume loss postcompression. Results indicate a decrease in Poisson ratio as a function of alginate …