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Full-Text Articles in Biomedical Engineering and Bioengineering
In Vivo Imaging Of Human Retinal Microvasculature Using Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography, Alexander Pinhas, Michael Dubow, Nishit Shah, Toco Y.P. Chui, Drew Scoles, Yusufu N. Sulai, Rishard Weitz, Joseph B. Walsh, Joseph Carroll, Alfredo Dubra, Richard B. Rosen
In Vivo Imaging Of Human Retinal Microvasculature Using Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography, Alexander Pinhas, Michael Dubow, Nishit Shah, Toco Y.P. Chui, Drew Scoles, Yusufu N. Sulai, Rishard Weitz, Joseph B. Walsh, Joseph Carroll, Alfredo Dubra, Richard B. Rosen
Biomedical Engineering Faculty Research and Publications
The adaptive optics scanning light ophthalmoscope (AOSLO) allows visualization of microscopic structures of the human retina in vivo. In this work, we demonstrate its application in combination with oral and intravenous (IV) fluorescein angiography (FA) to the in vivo visualization of the human retinal microvasculature. Ten healthy subjects ages 20 to 38 years were imaged using oral (7 and/or 20 mg/kg) and/or IV (500 mg) fluorescein. In agreement with current literature, there were no adverse effects among the patients receiving oral fluorescein while one patient receiving IV fluorescein experienced some nausea and heaving. We determined that all retinal capillary …
In Vivo Dark-Field Imaging Of The Retinal Pigment Epithelium Cell Mosaic, Drew Scoles, Yusufu N. Sulai, Alfredo Dubra
In Vivo Dark-Field Imaging Of The Retinal Pigment Epithelium Cell Mosaic, Drew Scoles, Yusufu N. Sulai, Alfredo Dubra
Biomedical Engineering Faculty Research and Publications
Non-invasive reflectance imaging of the human RPE cell mosaic is demonstrated using a modified confocal adaptive optics scanning light ophthalmoscope (AOSLO). The confocal circular aperture in front of the imaging detector was replaced with a combination of a circular aperture 4 to 16 Airy disks in diameter and an opaque filament, 1 or 3 Airy disks thick. This arrangement reveals the RPE cell mosaic by dramatically attenuating the light backscattered by the photoreceptors. The RPE cell mosaic was visualized in all 7 recruited subjects at multiple retinal locations with varying degrees of contrast and cross-talk from the photoreceptors. Various experimental …