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Articles 1 - 15 of 15

Full-Text Articles in Biomedical Engineering and Bioengineering

Optical Acquisition And Polar Decomposition Of The Full-Field Deformation Gradient Tensor Within A Fracture Callus, Wangdo Kim, Sean S. Kohles Oct 2013

Optical Acquisition And Polar Decomposition Of The Full-Field Deformation Gradient Tensor Within A Fracture Callus, Wangdo Kim, Sean S. Kohles

Sean S. Kohles

Tracking tissue deformation is often hampered by material inhomogeneity, so local measurements tend to be insufficient thus lending to the necessity of full-field optical measurements. This study presents a novel approach to factoring heterogeneous deformation of soft and hard tissues in a fracture callus by introducing an anisotropic metric derived from the deformation gradient tensor (F). The deformation gradient tensor contains all the information available in a Green-Lagrange strain tensor, plus the rigid-body rotational components. A recent study [Bottlang et al., J. Biomech. 41(3), 2008] produced full-field strains within ovine fracture calluses acquired through the application of electronic speckle ...


Prediction Of Growth Factor Effects On Engineered Cartilage Composition Using Deterministic And Stochastic Modeling, Sean S. Kohles, Asit K. Saha, J. (Jagannath) Mazumdar Oct 2013

Prediction Of Growth Factor Effects On Engineered Cartilage Composition Using Deterministic And Stochastic Modeling, Sean S. Kohles, Asit K. Saha, J. (Jagannath) Mazumdar

Sean S. Kohles

In the design of engineered tissues, guided balance of biomaterial degeneration with tissue synthesis offers refined control of construct development. The objective of this study was to develop a mathematical model that describes the steady state metabolism of extracellular matrix molecules (ECM: glycosaminoglycan and collagen) in an engineered cartilage construct taking into account localized environmental changes that may arise because of the application of growth factors. The variable effects of growth factors were incorporated in the form of random noise rather than the difference in rates of synthesis and catabolism. Thus, the frequency of ECM accumulation for each matrix molecule ...


Cytoskeletal Strains In Modeled Optohydrodynamically Stressed Healthy And Diseased Biological Cells, Sean S. Kohles, Yu Liang, Asit K. Saha Oct 2013

Cytoskeletal Strains In Modeled Optohydrodynamically Stressed Healthy And Diseased Biological Cells, Sean S. Kohles, Yu Liang, Asit K. Saha

Sean S. Kohles

Controlled external chemomechanical stimuli have been shown to influence cellular and tissue regeneration/degeneration, especially with regards to distinct disease sequelae or health maintenance. Recently, a unique three-dimensional stress state was mathematically derived to describe the experimental stresses applied to isolated living cells suspended in an optohydrodynamic trap (optical tweezers combined with microfluidics). These formulae were previously developed in two and three dimensions from the fundamental equations describing creeping flows past a suspended sphere. The objective of the current study is to determine the full-field cellular strain response due to the applied three-dimensional stress environment through a multiphysics computational simulation ...


A Study On Correlation Between Consciousness Level And Performance Of The Worker, Devendra Kumar Chaturvedi Dr., Manish Kumar Arya Aug 2013

A Study On Correlation Between Consciousness Level And Performance Of The Worker, Devendra Kumar Chaturvedi Dr., Manish Kumar Arya

Manish Kumar Arya

Consciousness is significantly related to workplace performance among managers and workers. A considerable amount of research indicates that consciousness is one of the best predictors of performance in the workplace. Conscious employees are generally more reliable, more motivated, and harder working. They have also lower rate of absenteeism and counterproductive work behaviours such as stealing and fighting with other employees. Furthermore, consciousness is the only personality trait that correlates with performance across all categories of jobs. This is a pilot study to determine the workers performance related with consciousness. The consciousness will be experimentally measured using the self developed sensor ...


Materials Education And Research In Art And Design: A New Role For Libraries (Program Booklet), Mark Pompelia Jun 2013

Materials Education And Research In Art And Design: A New Role For Libraries (Program Booklet), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Education And Research In Art And Design: A New Role For Libraries (Website), Mark Pompelia Jun 2013

Materials Education And Research In Art And Design: A New Role For Libraries (Website), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Education And Research In Art And Design: A New Role For Libraries (Survey Stats), Mark Pompelia Jun 2013

Materials Education And Research In Art And Design: A New Role For Libraries (Survey Stats), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Education And Research In Art And Design: A New Role For Libraries (Program Sheet), Mark Pompelia Jun 2013

Materials Education And Research In Art And Design: A New Role For Libraries (Program Sheet), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Collection Creation And Administration: A New Role For Libraries (White Paper), Mark Pompelia Jun 2013

Materials Collection Creation And Administration: A New Role For Libraries (White Paper), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

The Problem/Opportunity: To define, identify, and guide design-based materials collections in academic settings and foster community among those with existing collections and/or those considering creating and supporting one.

Contents and topics:

  1. What is a materials collection?
  2. Why have a materials collection?
  3. Acquisition strategies
  4. Organizational approaches
  5. Programming possibilities
  6. Symposium summary
  7. Resources


Reducing Selection Bias In Case-Control Studies From Rare Disease Registries, J. Alexander Cole, John S. Taylor, Thomas N. Hangartner, Neal J. Weinreb, Pramod K. Mistry, Aneal Khan Feb 2013

Reducing Selection Bias In Case-Control Studies From Rare Disease Registries, J. Alexander Cole, John S. Taylor, Thomas N. Hangartner, Neal J. Weinreb, Pramod K. Mistry, Aneal Khan

Thomas N. Hangartner

Background: In clinical research of rare diseases, where small patient numbers and disease heterogeneity limit study design options, registries are a valuable resource for demographic and outcome information. However, in contrast to prospective, randomized clinical trials, the observational design of registries is prone to introduce selection bias and negatively impact the validity of data analyses. The objective of the study was to demonstrate the utility of case-control matching and the risk-set method in order to control bias in data from a rare disease registry. Data from the International Collaborative Gaucher Group (ICGG) Gaucher Registry were used as an example. Methods ...


Revised Reference Curves For Bone Mineral Content And Areal Bone Mineral Density According To Age And Sex For Black And Non-Black Children: Results Of The Bone Mineral Density In Childhood Study, Babette S. Zemel, Heidi J. Kalkwarf, Vicente Gilsanz, Joan M. Lappe, Sharon Oberfield, John A. Shepherd, Margaret M. Frederick, Xangke Huang, Ming Lu, Soroosh Mahboubi, Thomas N. Hangartner, Karen K. Winer Feb 2013

Revised Reference Curves For Bone Mineral Content And Areal Bone Mineral Density According To Age And Sex For Black And Non-Black Children: Results Of The Bone Mineral Density In Childhood Study, Babette S. Zemel, Heidi J. Kalkwarf, Vicente Gilsanz, Joan M. Lappe, Sharon Oberfield, John A. Shepherd, Margaret M. Frederick, Xangke Huang, Ming Lu, Soroosh Mahboubi, Thomas N. Hangartner, Karen K. Winer

Thomas N. Hangartner

Context: Deficits in bone acquisition during growth may increase fracture risk. Assessment of bone health during childhood requires appropriate reference values relative to age, sex, and population ancestry to identify bone deficits. Objective: The objective of this study was to provide revised and extended reference curves for bone mineral content (BMC) and areal bone mineral density (aBMD) in children. Design: The Bone Mineral Density in Childhood Study was a multicenter longitudinal study with annual assessments for up to 7 yr. Setting: The study was conducted at five clinical centers in the United States. Participants: Two thousand fourteen healthy children (992 ...


Tracking Of Bone Mass And Density During Childhood And Adolescence, Heidi J. Kalkwarf, Vicente Gilsanz, Joan M. Lappe, Sharon Oberfield, John A. Shepherd, Thomas N. Hangartner, Xangke Huang, Margaret M. Frederick, Karen K. Winer, Babette S. Zemel Feb 2013

Tracking Of Bone Mass And Density During Childhood And Adolescence, Heidi J. Kalkwarf, Vicente Gilsanz, Joan M. Lappe, Sharon Oberfield, John A. Shepherd, Thomas N. Hangartner, Xangke Huang, Margaret M. Frederick, Karen K. Winer, Babette S. Zemel

Thomas N. Hangartner

Context: Whether a child with low bone mineral density (BMD) at one point in time will continue to have low BMD, despite continued growth and maturation, is important clinically. The stability of a characteristic during growth is referred to as “tracking.” Objective: We examined the degree of tracking in bone mineral content (BMC) and BMD during childhood and adolescence and investigated whether tracking varied according to age, sexual maturation, and changes in growth status. Design: We conducted a longitudinal study with measurements at baseline and annually for 3 yr. Setting: The Bone Mineral Density in Childhood Study was conducted at ...


Height Adjustment In Assessing Dual Energy X-Ray Absorptiometry Measurements Of Bone Mass And Density In Children, Babette S. Zemel, Mary B. Leonard, Andrea Kelly, Joan M. Lappe, Vicente Gilsanz, Sharon Oberfield, Soroosh Mahboubi, John A. Shepherd, Thomas N. Hangartner, Margaret M. Frederick, Karen K. Winer, Heidi J. Kalkwarf Feb 2013

Height Adjustment In Assessing Dual Energy X-Ray Absorptiometry Measurements Of Bone Mass And Density In Children, Babette S. Zemel, Mary B. Leonard, Andrea Kelly, Joan M. Lappe, Vicente Gilsanz, Sharon Oberfield, Soroosh Mahboubi, John A. Shepherd, Thomas N. Hangartner, Margaret M. Frederick, Karen K. Winer, Heidi J. Kalkwarf

Thomas N. Hangartner

Context: In children, bone mineral content (BMC) and bone mineral density (BMD) measurements by dual-energy x-ray absorptiometry (DXA) are affected by height status. No consensus exists on how to adjust BMC or BMD (BMC/BMD) measurements for short or tall stature. Objective: The aim of this study was to compare various methods to adjust BMC/BMD for height in healthy children. Design: Data from the Bone Mineral Density in Childhood Study (BMDCS) were used to develop adjustment methods that were validated using an independent cross-sectional sample of healthy children from the Reference Data Project (RDP). Setting: We conducted the study ...


Inhibition Of Bacillus Cereus Growth By Bacteriocin Producing Bacillus Subtilis Isolated From Fermented Baobab Seeds (Maari) Is Substrate Dependent, Donatien Kaboré, Dennis S. Nielsen, Hagrétoui Sawadogo-Lingan, Bréhima Diawara, Mamoudou H. Dicko Prof., Mogens Jakobsen, Line Thorsen Jan 2013

Inhibition Of Bacillus Cereus Growth By Bacteriocin Producing Bacillus Subtilis Isolated From Fermented Baobab Seeds (Maari) Is Substrate Dependent, Donatien Kaboré, Dennis S. Nielsen, Hagrétoui Sawadogo-Lingan, Bréhima Diawara, Mamoudou H. Dicko Prof., Mogens Jakobsen, Line Thorsen

Pr. Mamoudou H. DICKO, PhD

Maari is a spontaneously alkaline fermented food condiment made from baobab tree seeds. Due to the spontaneous nature of maari fermentations growth of the opportunistic human pathogen Bacillus cereus is occasionally observed. Bacillus subtilis strains are important for alkaline seed fermentations because of their enzymatic activities contributing to desirable texture, flavor and pH development. Some B. subtilis strains have antimicrobial properties against B. cereus. In the present work, three bacteriocin producing B. subtilis strains (B3, B122 and B222) isolated from maari were tested. The production of antimicrobial activity by the three strains was found to be greatly influenced by the ...


Evaluation Of Interpolation Effects On Upsampling And Accuracy Of Cost Functions-Based Optimized Automatic Image Registration, Amir Pasha Mahmoudzadeh, Nasser H. Kashou Jan 2013

Evaluation Of Interpolation Effects On Upsampling And Accuracy Of Cost Functions-Based Optimized Automatic Image Registration, Amir Pasha Mahmoudzadeh, Nasser H. Kashou

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Interpolation has become a default operation in image processing and medical imaging and is one of the important factors in the success of an intensity-based registration method. Interpolation is needed if the fractional unit of motion is not matched and located on the high resolution (HR) grid. The purpose of this work is to present a systematic evaluation of eight standard interpolation techniques (trilinear, nearest neighbor, cubic Lagrangian, quintic Lagrangian, hepatic Lagrangian, windowed Sinc, B-spline 3rd order, and B-spline 4th order) and to compare the effect of cost functions (least squares (LS), normalized mutual information (NMI), normalized cross correlation (NCC ...