Biomedical Engineering and Bioengineering Commons^™

Parallel Recording Of Neurotransmitters Release From Chromaffin Cells Using A 10 X 10 Cmos Ic Potentiostat Array With On-Chip Working Electrodes, Brian Kim, Adam Herbst, Sung Kim, Bradley Minch, Manfred Lindau

Bradley Minch

Neurotransmitter release is modulated by many drugs and molecular manipulations. We present an active CMOS-based electrochemical biosensor array with high throughput capability (100 electrodes) for on-chip amperometric measurement of neurotransmitter release. The high-throughput of the biosensor array will accelerate the data collection needed to determine statistical significance of changes produced under varying conditions, from several weeks to a few hours. The biosensor is designed and fabricated using a combination of CMOS integrated circuit (IC) technology and a photolithography process to incorporate platinum working electrodes on-chip. We demonstrate the operation of an electrode array with integrated high-gain potentiostats and output time-division …