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Full-Text Articles in Biomedical Engineering and Bioengineering

Pre-Amplifiers For A 15-Tesla Magnetic Resonance Imager, Chin-Leong Lim, Peter Serano, Jerome L. Ackerman Nov 2013

Pre-Amplifiers For A 15-Tesla Magnetic Resonance Imager, Chin-Leong Lim, Peter Serano, Jerome L. Ackerman

Chin-Leong Lim

High-field magnetic resonance imagers (MRI) give better signal-to-noise ratio (SNR) and image contrast. However clinical MRIs are currently limited to 3 Tesla (T) magnetic field strength. To create an uncommon 15 T scanner for research use, we evaluated several low-cost, intended for wireless communication, GaAs enhancement-mode pseudomorphic high electron mobility transistors (ePHEMT) in the critical preamplifier slot. This paper reports the experimental results that were obtained at both module and system levels. When evaluated in our prototype 15 T scanner front-end’s preamplifier slot, the candidate devices’ sub 1dB noise figures enabled image SNR ~ 110 in a water phantom (test …


Development Of A Novel Handheld Device For Active Compensation Of Physiological Tremor, Abhijit Saxena Jul 2013

Development Of A Novel Handheld Device For Active Compensation Of Physiological Tremor, Abhijit Saxena

Abhijit Saxena

In microsurgery, the human hand imposes certain limitations in accurately positioning the tip of a device such as scalpel. Any errors in the motion of the hand make microsurgical procedures difficult and involuntary motions such as hand tremors can make some procedures significantly difficult to perform. This is particularly true in the case of vitreoretinal microsurgery. The most familiar source of involuntary motion is physiological tremor. Real-time compensation of tremor is, therefore, necessary to assist surgeons to precisely position and manipulate the tool-tip to accurately perform a microsurgery. In this thesis, a novel handheld device (AID) is described for compensation …


Parallel Recording Of Neurotransmitters Release From Chromaffin Cells Using A 10 X 10 Cmos Ic Potentiostat Array With On-Chip Working Electrodes, Brian Kim, Adam Herbst, Sung Kim, Bradley Minch, Manfred Lindau Feb 2013

Parallel Recording Of Neurotransmitters Release From Chromaffin Cells Using A 10 X 10 Cmos Ic Potentiostat Array With On-Chip Working Electrodes, Brian Kim, Adam Herbst, Sung Kim, Bradley Minch, Manfred Lindau

Bradley Minch

Neurotransmitter release is modulated by many drugs and molecular manipulations. We present an active CMOS-based electrochemical biosensor array with high throughput capability (100 electrodes) for on-chip amperometric measurement of neurotransmitter release. The high-throughput of the biosensor array will accelerate the data collection needed to determine statistical significance of changes produced under varying conditions, from several weeks to a few hours. The biosensor is designed and fabricated using a combination of CMOS integrated circuit (IC) technology and a photolithography process to incorporate platinum working electrodes on-chip. We demonstrate the operation of an electrode array with integrated high-gain potentiostats and output time-division …


Nanoenabled Microelectromechanical Sensor For Volatile Organic Chemical Detection, Chiara Zuniga, Matteo Rinaldi, Samuel M. Khamis, A. T. Johnson, Gianluca Piazza Feb 2013

Nanoenabled Microelectromechanical Sensor For Volatile Organic Chemical Detection, Chiara Zuniga, Matteo Rinaldi, Samuel M. Khamis, A. T. Johnson, Gianluca Piazza

Matteo Rinaldi

A nanoenabled gravimetric chemical sensor prototype based on the large scale integration of single-stranded DNA (ss-DNA) decorated single-walled carbon nanotubes (SWNTs) as nanofunctionalization layer for aluminum nitride contour-mode resonant microelectromechanical (MEM) gravimetric sensors has been demonstrated. The capability of two distinct single strands of DNA bound to SWNTs to enhance differently the adsorption of volatile organic compounds such as dinitroluene (simulant for explosive vapor) and dymethyl-methylphosphonate (simulant for nerve agent sarin) has been verified experimentally. Different levels of sensitivity (17.3 and 28 KHz µm^2/fg) due to separate frequencies of operation (287 and 450 MHz) on the same die have also …