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Biomedical Engineering and Bioengineering Commons™
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Brain injury biomechanics; brain material; controlled cortical impact; finite element method; heterogeneous hippocampus injury; rat brain modeling
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Full-Text Articles in Biomedical Engineering and Bioengineering
Why Is Ca3 More Vulnerable Than Ca1 In Experimental Models Of Controlled Cortical Impact-Induced Brain Injury?, Haojie Mao, Benjamin S. Elkin, Vinay V. Genthikatti, Barclay Morrison Iii, King H. Yang
Why Is Ca3 More Vulnerable Than Ca1 In Experimental Models Of Controlled Cortical Impact-Induced Brain Injury?, Haojie Mao, Benjamin S. Elkin, Vinay V. Genthikatti, Barclay Morrison Iii, King H. Yang
Biomedical Engineering Faculty Research Publications
One interesting finding of controlled cortical impact (CCI) experiments is that the CA3 region of the hippocampus, which is positioned further from the impact than the CA1 region, is reported as being more injured. The current literature has suggested a positive correlation between brain tissue stretch and neuronal cell loss. However, it is counterintuitive to assume that CA3 is stretched more during CCI injury. Recent mechanical studies of the brain have reported on a level of spatial heterogeneity not previously appreciated—the finding that CA1 was significantly stiffer than all other regions tested and that CA3 was one of the most …