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Articles 1 - 14 of 14

Full-Text Articles in Biomedical Engineering and Bioengineering

Adhesive Elastomeric Proteins, Haefa Mansour, Julie Liu Oct 2013

Adhesive Elastomeric Proteins, Haefa Mansour, Julie Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Sutures and staples commonly used to close surgical wounds tend to be much stiffer than the surrounding tissue, often resulting in external tissue damage. Surgical adhesives provide a promising alternative to these sutures and staples. Ideal surgical adhesives are biocompatible, able to set well and remain sticky in moist conditions, possess strong adhesive and cohesive properties, and exhibit mechanical properties that mimic those of the surrounding tissue. Unfortunately, the adhesives available today are unable to satisfactorily meet all of these criteria. We are utilizing protein engineering techniques to design, create, and test a new surgical adhesive that combines the adhesive ...


Understanding Biocatalyst Inhibition By Carboxylic Acids, Laura R. Jarboe, Liam Royce, Ping Liu Sep 2013

Understanding Biocatalyst Inhibition By Carboxylic Acids, Laura R. Jarboe, Liam Royce, Ping Liu

Chemical and Biological Engineering Publications

Carboxylic acids are an attractive biorenewable chemical in terms of their flexibility and usage as precursors for a variety of industrial chemicals. It has been demonstrated that such carboxylic acids can be fermentatively produced using engineered microbes, such as Escherichia coli andSaccharomyces cerevisiae. However, like many other attractive biorenewable fuels and chemicals, carboxylic acids become inhibitory to these microbes at concentrations below the desired yield and titer. In fact, their potency as microbial inhibitors is highlighted by the fact that many of these carboxylic acids are routinely used as food preservatives. This review highlights the current knowledge regarding the ...


Effect Of Plant Hormones On The Production Of Biomass And Lipid In Microalgae, Malihe Mehdizadeh Allaf Aug 2013

Effect Of Plant Hormones On The Production Of Biomass And Lipid In Microalgae, Malihe Mehdizadeh Allaf

Electronic Thesis and Dissertation Repository

Limited fossil fuel reserves, increasing demand for energy in all parts of the world are some driving forces to look for new sources of transportation fuels. Among different options available, microalgae are currently attracting wide interests as an alternative and renewable fuel source.

Microalgae are single cell photosynthetic organisms that are known for rapid growth and high energy content and as a part of photosynthesis; they produce oil that can be used as a feedstock for biodiesel production. Some algae strains could contain lipid up to 80% of the dry biomass. The amount of lipid production is in direct relation ...


Materials Education And Research In Art And Design: A New Role For Libraries (Program Booklet), Mark Pompelia Jun 2013

Materials Education And Research In Art And Design: A New Role For Libraries (Program Booklet), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Education And Research In Art And Design: A New Role For Libraries (Website), Mark Pompelia Jun 2013

Materials Education And Research In Art And Design: A New Role For Libraries (Website), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Education And Research In Art And Design: A New Role For Libraries (Survey Stats), Mark Pompelia Jun 2013

Materials Education And Research In Art And Design: A New Role For Libraries (Survey Stats), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Education And Research In Art And Design: A New Role For Libraries (Program Sheet), Mark Pompelia Jun 2013

Materials Education And Research In Art And Design: A New Role For Libraries (Program Sheet), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Collection Creation And Administration: A New Role For Libraries (White Paper), Mark Pompelia Jun 2013

Materials Collection Creation And Administration: A New Role For Libraries (White Paper), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

The Problem/Opportunity: To define, identify, and guide design-based materials collections in academic settings and foster community among those with existing collections and/or those considering creating and supporting one.

Contents and topics:

  1. What is a materials collection?
  2. Why have a materials collection?
  3. Acquisition strategies
  4. Organizational approaches
  5. Programming possibilities
  6. Symposium summary
  7. Resources


Sol-Gel Derived Biodegradable And Bioactive Organic-Inorganic Hybrid Biomaterials For Bone Tissue Engineering, Bedilu A. Allo Apr 2013

Sol-Gel Derived Biodegradable And Bioactive Organic-Inorganic Hybrid Biomaterials For Bone Tissue Engineering, Bedilu A. Allo

Electronic Thesis and Dissertation Repository

Treatments of bone injuries and defects have been largely centered on replacing the lost bone with tissues of allogeneic or xenogeneic sources as well as synthetic bone substitutes, which in all lead to limited degree of structural and functional recovery. As a result, tissue engineering has emerged as a viable technology to regenerate the structures and therefore recover the functions of bone tissue rather than replacement alone. Hence, the current strategies of bone tissue engineering and regeneration rely on bioactive scaffolds to mimic the natural extracellular matrix (ECM) as templates onto which cells attach, multiply, migrate and function.

In this ...


Picture Of A Chelate In Exchange: The Crystal Structure Of Nahodotma, A 'Semi'-Hydrated Chelate, Katherine M. Payne, Edward J. Valente, Silvio Aime, Mauro Botta, Mark Woods Feb 2013

Picture Of A Chelate In Exchange: The Crystal Structure Of Nahodotma, A 'Semi'-Hydrated Chelate, Katherine M. Payne, Edward J. Valente, Silvio Aime, Mauro Botta, Mark Woods

Chemistry Faculty Publications and Presentations

Crystallography generally only provides static structural information. This can render it an ineffective technique for probing dynamic solution state processes. A crystal of HoDOTMA affords unique structures that effectively represent that of a lanthanide tetra-acetate chelate mid-way through the water exchange process.


Substrate Binding By The Catalytic Domain And Carbohydrate Binding Module Of Ruminococcus Flavefaciens Fd-1 Xyloglucanase/ Endoglucanase, Christopher D. Warner, Gulden Camci-Unal, Nicola L.B. Pohl, Clark Ford, Peter J. Reilly Jan 2013

Substrate Binding By The Catalytic Domain And Carbohydrate Binding Module Of Ruminococcus Flavefaciens Fd-1 Xyloglucanase/ Endoglucanase, Christopher D. Warner, Gulden Camci-Unal, Nicola L.B. Pohl, Clark Ford, Peter J. Reilly

Chemical and Biological Engineering Publications

Binding and thermodynamic properties of a carbohydrate binding module (CBM) and a glycoside hydrolase family 44 xyloglucanase/endoglucanase catalytic domain (CD) fromRuminococcus flavefaciens, both when separate and when linked to each other, have been quantified when binding various β-1,4-linked glucans and xylans. The three constructs bind cellotetraose, cellopentaose, and cellohexaose with association constants that increase with chain length. The CBM does not bind xylotetraose, xylopentaose, or xylohexaose. The CD appears to bind carboxymethylcellulose (CMC) and xylan only weakly, while the CBM and the CD/CBM bind them much more strongly than they bind the cellooligosaccharides. CMC is bound ...


Microfluidic Devices Applied On Enriching Post –Translational Modified Proteins For Proteomics, Hui Xia Jan 2013

Microfluidic Devices Applied On Enriching Post –Translational Modified Proteins For Proteomics, Hui Xia

Doctoral Dissertations

In this work, microfluidic devices were developed for enriching post-translational modified proteins. Post-translational modifications (PTM) of proteins play essential roles in cellular physiology and disease. The identification of protein substrates and detection of modification site helps understand PTM-mediated regulation in essential biological pathways and functions in various diseases. However, PTM proteins are typically present only at trace levels, making them difficult to identify in mass spectrometry based proteomics. This work study is about the design, fabrication and testing of the microfluidic device for the enrichment of abundant amount of PTMs. Carbonylated protein is used as a representative PTM to illustrate ...


Integrated Self-Assembly Of The Mms6 Magnetosome Protein To Form An Iron-Responsive Structure, Shuren Feng, Lijun Wang, Pierre Palo, Xunpei Liu, Surya K. Mallapragada, Marit Nilsen-Hamilton Jan 2013

Integrated Self-Assembly Of The Mms6 Magnetosome Protein To Form An Iron-Responsive Structure, Shuren Feng, Lijun Wang, Pierre Palo, Xunpei Liu, Surya K. Mallapragada, Marit Nilsen-Hamilton

Chemical and Biological Engineering Publications

A common feature of biomineralization proteins is their self-assembly to produce a surface consistent in size with the inorganic crystals that they produce. Mms6, a small protein of 60 amino acids from Magnetospirillum magneticum strain AMB-1 that promotes the in vitro growth of superparamagnetic magnetite nanocrystals, assembles in aqueous solution to form spherical micelles that could be visualized by TEM and AFM. The results reported here are consistent with the view that the N and C-terminal domains interact with each other within one polypeptide chain and across protein units in the assembly. From studies to determine the amino acid residues ...


Growth Condition Optimization For Docosahexaenoic Acid (Dha) Production By Moritella Marina Mp-1, Kumar Babu Kautharapu, John A. Rathmacher, Laura R. Jarboe Jan 2013

Growth Condition Optimization For Docosahexaenoic Acid (Dha) Production By Moritella Marina Mp-1, Kumar Babu Kautharapu, John A. Rathmacher, Laura R. Jarboe

Chemical and Biological Engineering Publications

The marine organism Moritella marina MP-1 produces the polyunsaturated fatty acid docosahexaenoic acid (DHA). While the basic metabolic pathway for DHA production in this organism has been identified, the impact of growth conditions on DHA production is largely unknown. This study examines the effect of supplemental carbon, nitrogen and salts, growth temperature and media composition and pH on DHA and biomass production and the fatty acid profile. The addition of supplemental nitrogen significantly increased the overall DHA titer via an increase in biomass production. Supplemental glucose or glycerol increased biomass production, but decreased the amount of DHA per biomass, resulting ...