Biomedical Engineering and Bioengineering Commons^™

Evaluation Of A Novel Self-Assembled Nanocoating In Promoting Bone On-Growth And Apposition On Metal, Hani Ghazi

Dissertations and Theses

"Loosening of metal is the leading cause of clinical failures of orthopedic surgeries. A novel coating of self-assembled monolayer of phosphonate molecules (SAMP) that chemically enhances metallic surfaces by covalently bonding to their naturally occurring oxidized surfaces has been developed.1 The SAMP coating is chemically stable, and its in-vitro results showed that it promotes cell proliferation, osteoblast adhesion and enhances biological attachment to metal surfaces.1 The purpose of this study is to establish the efficacy of this novel chemical surface treatment in improving the fixation of metallic implants in both cortical and cancellous bone over a conventional untreated implant. We …