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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
A Computational Investigation For Potential Improvements, Angela Grujicic
A Computational Investigation For Potential Improvements, Angela Grujicic
All Theses
Mild traumatic brain injury (mTBI), colloquially known as a concussion, is the most common injury in modern wars. This domination of mTBI is hypothesized to be due to a combination of unconventional explosives and better protection and care of the patients, increasing survivability. While the majority of the body is covered in armor, the head is left relatively unprotected. The current Advanced Combat Helmet (ACH) has been designed to protect the warfighter against ballistic impacts and impacts against a hard surface, with little to no regard to blast loading. Polyureas, a class of microsegregated, elastomeric copolymers, has been shown to …
'Exploring The Potential Of Using Antimicrobial Peptides And Copper Nanoparticles In Tackling Surgical Site Infections', Sriram Sankar
'Exploring The Potential Of Using Antimicrobial Peptides And Copper Nanoparticles In Tackling Surgical Site Infections', Sriram Sankar
All Theses
Postoperative wound site infections remain a major source of illness with approximately 500,000 infections per year, among an estimated 27 million surgical procedures. Such infections account for approximately one quarter of the estimated 2 million nosocomial infections in the United States which causes about 90,000 deaths each year. More than 70% of the bacteria that causes such infections are resistant to at least one of the antibiotics and result in longer hospitalization; besides requiring second option treatments that may be less effective, more toxic and expensive. Hence, there is a frenetic search for alternatives and in this regard, antimicrobial peptides …
Vascular Smooth Muscle Cells In Response To Gold Nanoparticles, William Mcallister
Vascular Smooth Muscle Cells In Response To Gold Nanoparticles, William Mcallister
All Theses
In this master's thesis we look at elucidating the interactions between nanoparticles and cells. Specifically, we looked at how the cell mechanics are affected, cytotoxicity of the nanoparticles, and shifts in cell phenotypes. There has been much research looking into whether nanoparticles are cytotoxic, but limited amounts looking at their effect on mechanics especially with vascular smooth muscle cells. This cell type has two distinct phenotypes of synthetic and contractile that each serve different purposes physiologically.
The first experiments we did were cytotoxicity assays to see if the cells could survive the treatment with nanoparticles. If the cells died within …
Effects Of Microenvironment On Growth And Differentiation Of Human Dental Pulp Cells, Laura Datko
Effects Of Microenvironment On Growth And Differentiation Of Human Dental Pulp Cells, Laura Datko
All Theses
Dental pulp stem cells (DPSCs) have recently been described as a potential stem cell source for various regenerative medicine and tissue engineering applications. They appear to be multipotent, however more characterization is necessary to determine the true potential of these cells. An important aspect of using DPSCs, or any stem cell type, tissue engineering application is the microenvironment within the construct. The microenvironment could include construct mechanical properties, construct composition, and 3D dynamic conditions in vivo. This work aims to study those specific microenvironment effects on DPSCs. To determine the effects of mechanical properties of the substrate on DPSCs, they …
Exploring The Potential Of Inkjet Printing For The Fabrication Of Tissue Test Systems, Vidya Seshadri
Exploring The Potential Of Inkjet Printing For The Fabrication Of Tissue Test Systems, Vidya Seshadri
All Theses
Animal models and two-dimensional assays involved in drug testing, vaccine development and basic scientific discovery are not an accurate representation of the human body; hence there is a need to develop new bench top methodologies which are better suited to yield information about in vivo behavior. There is a paucity of reliable in vitro-derived information regarding the reasons for the cause and progression of diseases. These concerns have lead to the development of three-dimensional systems which can facilitate improved understanding of disease etiology and also can bridge the path to the clinic.
The long term goal, beyond the scope of …