Biomedical Engineering and Bioengineering Commons^™

Development Of A Toolbox For The Kinematic Evaluation Of Hands-Up Video Games, Brooke Marie Odle

Theses

Children with cerebral palsy (CP) often have limited upper extremity (UE) control, Virtual reality (VR) is a current technology being evaluated as a form of UE therapy for children with CP, The systems currently available have been developed with games that cannot be graded to match the skill level of children with severely impaired UE control. A novel video game platform, "Hands-Up", has been developed at New Jersey Institute of Technology. The platform features software that allows for the customization of games and encourages users to make purposeful UE movements. To quantify changes and improvement in movement due to increased …

Sensorimotor Experience In Virtual Environments, Katherine Grace August

Dissertations

The goal of rehabilitation is to reduce impairment and provide functional improvements resulting in quality participation in activities of life, Plasticity and motor learning principles provide inspiration for therapeutic interventions including movement repetition in a virtual reality environment, The objective of this research work was to investigate functional specific measurements (kinematic, behavioral) and neural correlates of motor experience of hand gesture activities in virtual environments stimulating sensory experience (VE) using a hand agent model. The fMRI compatible Virtual Environment Sign Language Instruction (VESLI) System was designed and developed to provide a number of rehabilitation and measurement features, to identify optimal …

Reliability Of Resting Brain Networks Using Fmri, Suril Rajeshkumar Gohel

Theses

Resting state FMRI studies on human subjects are primarily focused on elaborating effects of resting state brain networks on task induced paradigm and to check consistency of these networks between different groups of populations. Recent studies have shown consistency of RSFC networks within same subjects with intra-site and intra-session variation.

The primary objective of this study was to check consistency of resting state networks between sites and between different groups of people in spite of change in scanning parameters and population. A total of 437 subjects resting state FMRI data from six different sites were collected varying in age group …

An In Vitro Study To Characterize A New Automated High Throughput Neuronal Stretch Injury System, Nicolae Valerian Hususan

Theses

Traumatic brain injury (TBI) is one of the most prevalent long-term neurological conditions and its overall economic consequences rival that of stroke. Considering the importance of the topic, new models for studying TBI are often designed and created. Based on a model developed by the University of Pennsylvania, NJIT constructed a fully automated version, which injures neuronal cell cultures in uniaxial regime and provides the high experimental yield required in pharmaceutical and neuroscience studies.

In this investigation, a new methodology for culturing primary cortical neurons of rat origin was established. Viable cell cultures developed for the first time in NJIT …

Development Of An Experimental System To Determine The Contribution Of Titin And Collagen To Passive Stiffness Of Myocardium, Saurin Bharat Shah

Theses

Diastolic dysfunction is known to be a major factor for congestive heart failure in aged humans and other mammals. The main contributors to increase in the myocardial stiffness, hindering the cardiac mechanics, are alterations in intracellular titin and extracellular collagen matrix. Titin is a giant extensible protein, the third filament of striated muscle after actin and myosin, which provides elasticity to passive sarcomeres. The aim of this study is to develop an efficient experimental system that will prove to be instrumental in comparing the contribution of titin against collagen to the passive stiffness of cardiac muscle extracted from experimental animals …

In Vitro Comparison Of A New Stand-Alone Anterior Lumbar Interbody Cage Device With Established Fixation Techniques, Nitin Chawla

Theses

Around 70% of the population in the United States experience low back pain at some point of their lives, of these 4% underwent surgical intervention on the lumbar spine to relieve the pain. Spinal arthrodesis, i.e. joint fusion, is beneficial in many cases as the final option for patients suffering from certain types of low back pain (LBP). In order to promote solid fusion across a decompressed spinal segment, interbody spacers/cages are used with and without posterior instrumentation to provide an initial "rigid" fixation of the segment.

In this study three fresh/frozen human cadaveric lumbar spines were used. Each lumbar …

Deciphering The Biology Of Axon Stretch-Growth, Joseph R. Loverde

Theses

Traditional nerve regeneration strategies focus on growth cone-mediated growth, a form of nerve growth that occurs primarily during embryogenesis. Early axons continue to grow from the end distal to the soma, seeking targets on which to synapse. It is believed that once the axons synapse, stretch-growth takes over and is responsible for the great lengths achieved by nerves of the central and peripheral nervous systems. Recent work has demonstrated stretch-growth in vitro resulting in dramatically increased growth rates compared to the growth cone. Here, the aim was to decipher the underlying biology associated with axon stretch-growth using two approaches. First, …

Finger Walking Control Of A Two-Dimensional Walking Model Through Inverse Kinematics, Jordan Ratcliff

Theses

Those people who have spinal cord injuries (SCI) must remain in wheelchairs due to disruption of the neural signaling to their muscles. Functional electrical stimulation (FES) has proved itself to be an option for restoring some motion and some walking for the patient. Electrodes can either be placed on the skin or muscle to provide an electrical impulse that stimulates the muscles into contraction. Current systems provide buttons that use set functions for left and right steps with constant direction and size. It is desired however that the user be allowed a more natural and variable control method of controlling …

Dual Parametric Sensors For Highly Sensitive Nucleic Acid Detection, Manu Sebastian Mannoor

Theses

The primary focus of this research work was on the design and development of a molecular scale (nano-scale) capacitive sensing mechanism for the highly sensitive and label-free detection of Nucleic Acid hybridization. These novel capacitive sensors with nano-scale electrode spacing offer solutions to many problems suffered by the conventional signal transduction mechanisms, thereby immensely improving the sensitivity of the biomolecular detection processes. Reducing the separation between the capacitive electrodes to the same scale as the Debye length of the sample solution, results in the overlapping of the electrical double layers of the two electrodes, thereby confining them to occupy a …

Assessing Trainer Hand Forces For Manual Body Weight Supported Walking, Manish Raval

Theses

Spinal cord injuries occur in approximately 12,000 to 15,000 people per year in the U.S. About 10,000 of these people are permanently paralyzed. Most spinal cord traumas occur in young, healthy individuals. Males between 15 and 35 years old are most commonly affected.

Recently new approaches to facilitate walking recovery for individuals after a spinal cord injury, have been directed towards a therapy known as Locomotor Training (LT) that implements repetitive stepping on a treadmill using body weight support. A major intent of LT research is to investigate the effect of an extended period of LT on bilateral muscle activation …

Study And Development Of Ultrasound Monitoring Of Skeletal Defects, Kavil Patel

Theses

Fatigue fractures are fine disruptions of normal bone architecture whose identification is often unreliable or difficult using x-rays (Robinson, Wilson et al.; Kundel 2004; Swischuk and Hernandez 2004). A fatigue fracture results from the application of abnormal loads to a bone with normal elastic resistance and is associated with new or different activity, and strenuous or repeated activity. The feasibility of using ultrasound to detect and monitor fatigue fractures and other structural damage in bone was established in this study.

The use of Low Transient Pulse (LTP) technology to drive the ultrasound transducers proved to enhance detection resolution and quality …

Evaluation Of Medical Alarm Sounds, Elizbha Philip

Theses

Auditory alarms in medical equipments perform considerably below their optimal level. Concern has been expressed about the quality of medical alarms by a large number of researchers in recent years. A detailed literature survey on the medical alarm related problems has been carried out. Hospital visits were made to obtain real life information and data of alarm sounds in various type of monitors used in OR and ICU. A laboratory experiment has been conducted on selected melodic alarm sounds. These melodic alarm sounds are being implemented in medical equipments and the idea of design is proposed in ISO / IEC …

Aptamer-Based Nano-Scale Dielectric Sensor For Protein Detection, Teena James

Theses

The specific detection and precise quantification of protein molecules play an essential role in basic discovery research as well as in clinical practice. In this research work, a novel protein detection mechanism based on nanoscale dielectric sensor functionalized with aptamer probes is developed. This work has been done in collaboration with Rational Affinity Devices LLC. The use of aptamer based detection offers several advantages over the traditional labor intensive antibody based immunosensing. In the initial phase of the work, the binding affinities of rationally designed oligomers towards a specific protein molecule (IgG) was studied and optimized under varying conditions of …