Biomedical Engineering and Bioengineering Commons^™

Investigating Stiff-Knee Gait With Subject-Specific Simulations, Jeffrey A. Reinbolt, M. D. Fox, S. L. Delp

Jeffrey A. Reinbolt

No abstract provided.

Simulation-Based Treatment Planning For Knee Osteoarthritis, B. J. Fregly, Jeffrey A. Reinbolt

Jeffrey A. Reinbolt

No abstract provided.

Precision And Accuracy Of Thermal Calibration Of Atomic Force Microscopy Cantilevers, Nancy Burnham, G Matei, E Thoreson, J Pratt, D Newell

Nancy A. Burnham

To have confidence in force measurements made with atomic force microscopes(AFMs), the spring constant of the AFM cantilevers should be known with good precision and accuracy, a topic not yet thoroughly treated in the literature. In this study, we compared the stiffnesses of uncoated tipless uniform rectangular silicon cantilevers among thermal, loading, and geometric calibration methods; loading was done against an artifact from the National Institute of Standards and Technology (NIST). The artifact was calibrated at NIST using forces that were traceable to the International System of units. The precision and accuracy of the thermal method were found to be …

Benefits Of Automatic Differentiation For Biomechanical Optimizations, Jeffrey A. Reinbolt, B. J. Fregly

Jeffrey A. Reinbolt

No abstract provided.

Evaluation Of A Patient-Specific Cost Function To Predict The Influence Of Foot Path On The Knee Adduction Torque During Gait, B. J. Fregly, Jeffrey A. Reinbolt, B. I. Koh, T. L. Chmielewski

Jeffrey A. Reinbolt

No abstract provided.

Predicting Patient-Specific Gait Modifications For Knee Osteoarthritis Rehabilitation, B. J. Fregly, Jeffrey A. Reinbolt, K. L. Rooney, K. H. Mitchell, T. L. Chmielewski

Jeffrey A. Reinbolt

No abstract provided.

Substrate Rigidity Regulates The Formation And Maintenance Of Tissues, Nancy Burnham, Wei-Hui Guo, Margo Frey, Yu-Li Wang

Nancy A. Burnham

The ability of cells to form tissues represents one of the most fundamental issues in biology. However, it is unclear what triggers cells to adhere to one another in tissues and to migrate once a piece of tissue is planted on culture surfaces. Using substrates of identical chemical composition but different flexibility, we show that this process is controlled by substrate rigidity: on stiff substrates, cells migrate away from one another and spread on surfaces, whereas on soft substrates they merge to form tissue-like structures. Similar behavior was observed not only with fibroblastic and epithelial cell lines but also explants …

A Modified Hodgkin–Huxley Model, Ji-Huan He

Ji-Huan He

A modified Hodgkin–Huxley model is suggested by taking into account the size effect of ionic channels.

An Evaluation Of Osteoporosis Prevalence In Spinal Cord Disabled Veterans, Hossein Gholizadeh

Hossein Gholizadeh

DANESHVAR MEDICINE; DECEMBER 2006-JANUARY 2007; 14(66);37-44. AN EVALUATION OF OSTEOPOROSIS PREVALENCE IN SPINAL CORD DISABLED VETERANS SHOJAEI H.,SOROUSH M.R.,MODIRIAN E.,GHOLIZADEH H. Introduction: Osteoporosis and bone fracture risk due to decrease in bone mineral density is known as one of the most important complications of chronic spinal cord injuries (SCI). It also is a major health problem among the patients in SCI society. Although immobilization, old age, menopause and some comorbiditing, are major causes, other important factors also should be taken into consideration. Materials & Method: In this cross-sectional study, 132 veterans with SCI (mean of age 37.4 years), underwent dual-energy …

Heat And Mass Transfer (Baehr And Stephan), Dr Alireza Zolfaghari

Dr Alireza Zolfaghari

No abstract provided.

A Heat Transfer Textbook (Lienhard), Dr Alireza Zolfaghari

Dr Alireza Zolfaghari

No abstract provided.

Application Of E-Infinity Theory To Biology, Ji-Huan He

Ji-Huan He

Albert Einstein combined continuous space and time into his special relativity, El-Naschie discovered the transfinite discontinuity of space–time in his E-infinity theory where infinity of dimensions was created. We find a partner of both space–time and E-infinity in biology. In our theory, the number of cells in an organism endows an additional dimension in biology, leading to explanation of many complex phenomena.

Application Of E-Infinity Theory To Biology, Ji-Huan He

Ji-Huan He

Albert Einstein combined continuous space and time into his special relativity, El-Naschie discovered the transfinite discontinuity of space–time in his E-infinity theory where infinity of dimensions was created. We find a partner of both space–time and E-infinity in biology. In our theory, the number of cells in an organism endows an additional dimension in biology, leading to explanation of many complex phenomena.

Quantitative Measurement Of The Brã¶Nsted Acid Sites In Solid Acids: Toward A Single-Site Design Of Mo-Modified Zsm-5 Zeolite, Jean-Philippe Tessonnier, Benoit Louis, Stephane Walspurger, Jean Sommer, Marc-Jacques Ledoux, Cuong Pham-Huu

Jean-Philippe Tessonnier

On the basis of our previous H/D exchange studies devoted to the quantification of the number of Bro¨nsted acid sites in solid acids, we report here an innovative approach to determine both the amount and the localization of Mo atoms inside the Mo/ZSM-5 catalyst, commonly used for the methane dehydroaromatization reaction. The influence of Mo introduction in the MFI framework was studied by means of BET, X-ray diffraction, 27Al magic angle spinning NMR, NH3 temperature-programmed desorption, and H/D isotopic exchange techniques. A dependence was found between the decrease of acidic OH groups and the Mo content. Depending on the Si/Al …

Application Of Inkjet Printing To Tissue Engineering, Thomas Boland, Tao Xu, Brook Damon, Xiaofeng Cui

Thomas Boland

ecent advances in organ printing technology for applications relating to medical interventions and organ replacement are described. Organ printing refers to the placement of various cell types into a soft scaffold fabricated according to a computer-aided design template using a single device. Computer aided scaffold topology design has recently gained attention as a viable option to achieve function and mass transport requirements within tissue engineering scaffolds. An exciting advance pioneered in our laboratory is that of simultaneous printing of cells and biomaterials, which allows precise placement of cells and proteins within 3-D hydrogel structures. This advance raises the possibility of …

The Use Of Extracellular Matrix As An Inductive Scaffold For The Partial Replacement Of Functional Myocardium., Glenn Gaudette, S Badylak, P Kochupura, I Cohen, S Doronin, A Saltman, T Gilbert, D Kelly, R Ignotz

Glenn R. Gaudette

Regenerative medicine approaches for the treatment of damaged or missing myocardial tissue include cell-based therapies, scaffold-based therapies, and/or the use of specific growth factors and cytokines. The present study evaluated the ability of extracellular matrix (ECM) derived from porcine urinary bladder to serve as an inductive scaffold for myocardial repair. ECM scaffolds have been shown to support constructive remodeling of other tissue types including the lower urinary tract, the dermis, the esophagus, and dura mater by mechanisms that include the recruitment of bone marrow-derived progenitor cells, angiogenesis, and the generation of bioactive molecules that result from degradation of the ECM. …

Viability And Electrophysiology Of Neural Cell Structures Generated By The Inkjet Printing Method, Tao Xu, Cassie Gregory, Peter Molnar, S Jalota, Sarit Bhaduri, Thomas Boland

Thomas Boland

Complex cellular patterns and structures were created by automated and direct inkjet printing of primary embryonic hippocampal and cortical neurons. Immunostaining analysis and whole-cell patch-clamp recordings showed that embryonic hippocampal and cortical neurons maintained basic cellular properties and functions, including normal, healthy neuronal phenotypes and electrophysiological characteristics, after being printed through thermal inkjet nozzles. In addition, in this study a new method was developed to create 3D cellular structures: sheets of neural cells were layered on each other (layer-by-layer process) by alternate inkjet printing of NT2 cells and fibrin gels. These results and findings, taken together, show that inkjet printing …

Prospective Energy Densities In The Forisome, A New Smart Material, William Pickard, Michael Knoblauch, Winfried Peters, Amy Shen

Winfried S. Peters