Biomedical Engineering and Bioengineering Commons^™

Regulation Of Dna Replication Initiation By Histone Acetylation And The Dna Unwinding Element Binding Protein Due-B, Michael George Kemp

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Duplication of the genome during S phase of the mitotic cell cycle begins at thousands of sites along chromosomes termed origins of replication. Although many of the essential protein components catalyzing events at these sites are known and are conserved throughout eukaryotes, the likelihood or efficiency of initiation of DNA synthesis at any given genomic site is expected to be influenced by other novel factors, including aspects of chromatin and DNA structure.

Here I show that increased histone H4 acetylation at replication origin loci occurs after treatment with the histone deacetylase inhibitor TSA and coincides with a loss of specific …

Methodology For Quantifying Biomechanical Bone Movement Of Transtibial Amputations, Johanna C. Bell

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A controversy has long existed about an alternate below knee amputation procedure that may be more beneficial than the traditional transtibial amputation. The proponents of this alternate procedure that stabilizes the distal tibia and fibula claim it reduces excessive movement of the fibula relative to the tibia that occurs with common movements, such as walking. The purpose of this study is to develop a methodology for quantifying excessive movement of the fibula bone relative to the tibia bone in traditional below the knee amputations. The methodology will measure the movement and rotation of the fibula relative to the tibia. These …