Biomedical Engineering and Bioengineering Commons^™

Water Transport And The Distribution Of Aquaporin-1 In Pulmonary Air Spaces, Richard M. Effros, C. Darin, Elizabeth R. Jacobs, R. A. Rogers, Gary S. Krenz, E. E. Schneeberger

Biomedical Engineering Faculty Research and Publications

Recent evidence suggests that water transport between the pulmonary vasculature and air spaces can be inhibited by HgCl₂, an agent that inhibits water channels (aquaporin-1 and -5) of cell membranes. In the present study of isolated rat lungs, clearances of labeled (³HOH) and unlabeled water were compared after instillation of hypotonic or hypertonic solutions into the air spaces or injection of a hypotonic bolus into the pulmonary artery. The clearance of ³HOH between the air spaces and perfusate after intratracheal instillation and from the vasculature to the tissues after pulmonary arterial injections was invariably greater …

Laparoscopic Assisted Fusion Of The Lumbosacral Spine: A Biomechanical And Histologic Analysis Of The Open Versus Laparoscopic Technique In An Animal Model, Lee H. Riley Iii, Jason C. Eck, Hiryuki Yoshida, Jeffrey M. Toth, Nguyen Cahn, Tae Hong Lim, Linda M. Mcgrady

Biomedical Engineering Faculty Research and Publications

Study Design. An animal model for laparoscopic lumbosacral fusion.

Objectives. To compare the biomechanical and histologic results of open to laparoscopic lumbosacral discectomy and fusion in an animal model.

Background Data. Early clinical reports of laparoscopic lumbosacral fusions are encouraging, but animal experiments have not been reported.

Methods. Ten pigs (50-80 kg) were divided into two groups. Group 1 underwent an open anterior lumbosacral discectomy and fusion at L7-S1 using autologous bone graft and a titanium MOSS (DePuy Motech) cage. Group 2 was identical to Group 1 except that a laparoscopic technique was used. The animals were killed at 3 …

Experimental Spinal Fusion With Recombinant Human Bone Morphogenetic Protein-2 Without Decortication Of Osseous Elements, Harvinder Sandhu, Linda E.A. Kanim, Jeffrey M. Toth, J. Michael Kabo, David Liu, Rick B. Delamarter, Edgar G. Dawson

Biomedical Engineering Faculty Research and Publications

Study Design. L4-L5 intertransverse process fusions were produced with 58 μg, 230 μg, or 920 μg of recombinant human bone morphogenetic protein-2 in 20 dogs. Eleven had traditional decortication of posterior elements before insertion of the implant. Nine were left undecorticated. All animals were evaluated 3 months after surgery.

Objectives. To determine whether decortication is a prerequisite for successful fusion in the presence of osteoinductive proteins such as bone morphogenetic protein-2.

Summary of Background Data. Recombinant osteoinductive proteins can induce de novo bone in ectopic soft-tissue sites in the absence of bone marrow elements. Traditional methods for achieving spinal fusion …

Generic, Geometric Finite Element Analysis Of The Transtibial Residual Limb And Prosthetic Socket, Barbara Silver-Thorn, Dudley S. Childress

Biomedical Engineering Faculty Research and Publications

Finite element analysis was used to investigate the stress distribution between the residual limb and prosthetic socket of persons with transtibial amputation (TTA). The purpose of this study was to develop a tool to provide a quantitative estimate of prosthetic interface pressures to improve our understanding of residual limb/prosthetic socket biomechanics and prosthetic fit. FE models of the residual limb and prosthetic socket were created. In contrast to previous FE models of the prosthetic socket/residual limb system, these models were not based on the geometry of a particular individual, but instead were based on a generic, geometric approximation of the …