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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Letter To The Editor: Biocompatibility And Reactogenicity Of Materials: A Semantic And Logical Analysis Of Definitions And Their Practical Significance, Leonid I. Slutskii, Janis J. Vetra
Letter To The Editor: Biocompatibility And Reactogenicity Of Materials: A Semantic And Logical Analysis Of Definitions And Their Practical Significance, Leonid I. Slutskii, Janis J. Vetra
Cells and Materials
Any biomaterial implanted into a living body elicits a distinct local reaction. This reaction depends on the physical, physico-chemical and chemical properties of the material. The obvious term to designate this inherent property of a biomaterial to induce a local reaction is reactogenicity. Reactogenicity of a biomaterial is one of the main factors determining (together with other properties of the implanted device) the bio(non)compatibility of the implant. Such amplification of terminology which establishes differences between biocompatibility as a generalized characteristic of biomaterials in all their interrelations with the host's organism and the influences on local processes around implants, makes the …
A Composite Biomaterial: Poly 2 (Hydropoxyethyl) Methacrylate / Alkaline Phosphatase Initiates Mineralization In Vitro, R. Filmon, D. Chappard, J. P. Monthéard, M. F. Baslé
A Composite Biomaterial: Poly 2 (Hydropoxyethyl) Methacrylate / Alkaline Phosphatase Initiates Mineralization In Vitro, R. Filmon, D. Chappard, J. P. Monthéard, M. F. Baslé
Cells and Materials
Bone substitutes are nowadays largely used in orthopedic surgery but they lack osteoinductive properties. Poly (2-hydroxyethyl methacrylate) (pHEMA) has numerous biomedical applications. Alkaline phosphatase (AlkP), an ectoenzyme elaborated by osteoblasts, initiates bone mineralization by hydrolyzing organic phosphates before calcium-phosphorus deposition. We have immobilized AlkP in pHEMA in a copolymerization technic. Histochemical study revealed that AlkP has retained its biological activity . Image analysis of sections using a tessellation method showed a lognormal distribution of the area of tessels around AlkP particles thus confirming an homogeneous distribution of the enzyme in the polymer. Pellets of pHEMA and pHEMA + AlkP were …