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An In Vitro Evaluation Of Dbm As A Tissue Engineered Scaffold, Stephanie Arnold
An In Vitro Evaluation Of Dbm As A Tissue Engineered Scaffold, Stephanie Arnold
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Over 500,000 bone graft procedures are performed each year in the United States. Bone grafting involves a surgical procedure to replace missing bone. Problems can arise with donor and defect sites during and after surgery, sometimes resulting in poor clinical results. The development and optimization of bone graft substitutes via a tissue engineering approach could markedly improve bone graft surgical outcome. Demineralized bone matrix (DBM), a bone graft material, is currently used in a clinical setting but has variable success rates.
The primary objective of the research presented in this thesis was to assess the cellular activity of D1 mouse …
Fabrication And Testing Of Scaffolds For Cell Growth From Ionic Liquid Solubilized Fibroin, Maneesh Kumar Gupta
Fabrication And Testing Of Scaffolds For Cell Growth From Ionic Liquid Solubilized Fibroin, Maneesh Kumar Gupta
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The advent of tissue engineering has spurred research into developing materials to act as scaffolds for tissue growth. These scaffolds require materials capable of mimicking the in vivo conditions so that tissues can be grown effectively in vitro. Silk is an attractive biomaterial for use in tissue engineering applications because of its slow degradation, excellent mechanical properties, and biocompatibility. The major objective of the research in this thesis is to demonstrate a simple method to cast films directly from silk fibroin dissolved in an ionic liquid. The films cast from the silk ionic liquid solution were found to support normal …