Open Access. Powered by Scholars. Published by Universities.®

Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Theses/Dissertations

Nanoparticles

Analytical, Diagnostic and Therapeutic Techniques and Equipment

Articles 1 - 1 of 1

Full-Text Articles in Biomedical Engineering and Bioengineering

Targeted Multistage Delivery Of Nanoparticles To The Bone Marrow, Aman Mann Aug 2011

Targeted Multistage Delivery Of Nanoparticles To The Bone Marrow, Aman Mann

UT GSBS Dissertations and Theses (Open Access)

Bone marrow is a target organ site involved in multiple diseases including myeloproliferative disorders and hematologic malignancies and metastases from breast and prostate. Most of these diseases are characterized with poor quality of life, and the treatment options are only palliative due to lack of delivery mechanisms for systemically injected drugs which results in dose limitation to protect the healthy hematopoietic cells. Therefore, there is a critical need to develop effective therapeutic strategies that allow for selective delivery of therapeutic payload to the bone marrow. Nanotechnology-based drug delivery systems provide the opportunity to deliver drugs to the target tissue while ...