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Full-Text Articles in Biomedical Engineering and Bioengineering
Modeling And Validation Of Tissue Optical Properties In The Photon Transport Regime, Katelyn Heath
Modeling And Validation Of Tissue Optical Properties In The Photon Transport Regime, Katelyn Heath
Biomedical Engineering Undergraduate Honors Theses
Early detection of changes in epithelial cells, such as the development of neoplastic formations seen in epithelial dysplasia, can indicate regions of the epithelial tissue that are at a high risk for cancerous formation. Using concepts from diffuse reflectance spectroscopy, a Monte Carlo model was developed to predict the reflectance measured by a detector at a small source-detector separation on a microendoscope. The Monte Carlo results were then used to calculate a mathematical relationship between the reflectance and distance that can be used to determine optical properties in a tissue sample. This model was validated with liquid phantoms of specified …
Three-Dimensional Collagen Tubes For In Vitro Modeling, Rebecca Jones
Three-Dimensional Collagen Tubes For In Vitro Modeling, Rebecca Jones
Theses and Dissertations
Collagen type I represents a novel material for three-dimensional in vitro models. While two-dimensional models are typically inadequate for recreating the complex processes of the body, collagen provides a three-dimensional basis with a variety of applications, including remodeling of vascular cells under tension and vascular stenosis. Smooth muscle cells reorganize and reconstruct their environment differently under conditions of tensions, such as with sutures, or under conditions without applied external tension. Vascular stenosis, the abnormal narrowing of blood vessels, arises from defective developmental processes or atherosclerosis-related adult pathologies. Stenosis triggers a series of adaptive cellular responses that induces adverse remodeling, which …