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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Computer-Aided, Multi-Modal, And Compression Diffuse Optical Studies Of Breast Tissue, David R. Busch Jr Dec 2011

Computer-Aided, Multi-Modal, And Compression Diffuse Optical Studies Of Breast Tissue, David R. Busch Jr

Publicly Accessible Penn Dissertations

Diffuse Optical Tomography and Spectroscopy permit measurement of important physiological parameters non-invasively through ~10 cm of tissue. I have applied these techniques in measurements of human breast and breast cancer. My thesis integrates three loosely connected themes in this context: multi-modal breast cancer imaging, automated data analysis of breast cancer images, and microvascular hemodynamics of breast under compression. As per the first theme, I describe construction, testing, and the initial clinical usage of two generations of imaging systems for simultaneous diffuse optical and magnetic resonance imaging. The second project develops a statistical analysis of optical breast data from many spatial ...


Chemical And Biological Strategies For Improving The Sensitivity Of Spio-Enhanced Mr Imaging, Andrew Elias Aug 2011

Chemical And Biological Strategies For Improving The Sensitivity Of Spio-Enhanced Mr Imaging, Andrew Elias

Publicly Accessible Penn Dissertations

The prevalence of cancer has seen significant growth over the last three decades, with the American Cancer Society now reporting that one in every three Americans will be afflicted with some form of cancer in their lifetime. The debilitating effects of cancer permeate beyond obvious biological ramifications, often adversely affecting patients on emotional and financial levels as well. While significant progress has been made in diagnosing and treating cancer, advancements are still needed in detecting and treating cancers at earlier stages, where clinical outcomes will be more favorable. The field of cellular and molecular imaging has emerged as a cutting-edge ...


Characterizing Cartilage-Specific T1rho Mri For Clinical Translation And Application, Noelle F. Klocke Jul 2011

Characterizing Cartilage-Specific T1rho Mri For Clinical Translation And Application, Noelle F. Klocke

Theses and Dissertations

T1rho MRI, spin-lattice relaxation in the rotating frame, is postulated to be sensitive to early biochemical changes within articular cartilage that may lead to osteoarthritis. This means that it has potential as a non-invasive, early biomarker for disease progression. However, T1rho has been primarily studied in a research setting. Therefore, the main question posed in this work is:

Can T1rho MRI be used in an at-risk population (ACL-rupture patients) and translated to a clinical setting?

To answer this question, two tools (Relaxometry program, Line Profile Analysis) were created and validated for measuring T1rho within living subjects. These tools were used ...


Traumatic Vs. Pathological Achilles Tendon Ruptures: A Look Into The Importance Of The Collagen Matrix And The Preferred Method Of Repair, Kathleen M. Mclean Jun 2011

Traumatic Vs. Pathological Achilles Tendon Ruptures: A Look Into The Importance Of The Collagen Matrix And The Preferred Method Of Repair, Kathleen M. Mclean

Honors Theses

The Achilles tendon is the largest, strongest, and thickest tendon in the human body. While it may be the strongest, the Achilles tendon is also among one of the most frequently ruptured. These lower limb injuries arise as a result of athletically induced trauma or pathologically and steroidal induced trauma. While the manner in which athletic ruptures occurs can be determined on a case to case basis through the use of clinical examination, ultrasonography, and magnetic resonance imaging (MRI), the method in which the injury should be treated remains controversial. The two main methods of repair include a conservative approach ...


Indirect Detection Of Axonal Architecture With Q-Space Imaging, Henry H. Ong May 2011

Indirect Detection Of Axonal Architecture With Q-Space Imaging, Henry H. Ong

Publicly Accessible Penn Dissertations

Evaluating axon morphology would provide insights into connectivity, maturation, and disease pathology. Conventional diffusion MRI can provide metrics that are related to axon morphology, but cannot measure specific parameters such as mean axon diameter (MAD) and intracellular fraction (ICF). Q-space imaging (QSI) is an advanced diffusion MRI technique that may be able to provide more information on axon morphology. However, QSI has several limitations that affect its implementation and accuracy.

The main objective of this dissertation was to address these limitations and to evaluate the potential of QSI to accurately assess axon morphology. First, a custom-built high-amplitude gradient coil was ...


Sar Map Of Gel Phantom In A 64mhz Mri Birdcage By Fiber-Optic Thermometry And Fdtd Simulation, Chirag Mukesh Patel Feb 2011

Sar Map Of Gel Phantom In A 64mhz Mri Birdcage By Fiber-Optic Thermometry And Fdtd Simulation, Chirag Mukesh Patel

Master's Theses and Project Reports

As implantable medical devices are being used more often to treat medical problems for which pharmaceuticals don’t suffice, it is important to understand their interactions with commonly used medical modalities. The interactions between medical implants and Magnetic Resonance Imaging machines have proven to be a risk for patients with implants.

Implanted medical devices with elongated metallic components can create harmful levels of local heating in a Magnetic Resonance Imaging (MRI) environment [1]. The heating of a biological medium under MRI is monitored via the Specific Absorption Rate (SAR). SAR, defined as power absorbed per unit mass (W/kg), can ...


Investigations Of Anatomical Connectivity In The Internal Capsule Of Macaques With Diffusion Magnetic Resonance Imaging, Kyle Andrew Ignatius Taljan Jan 2011

Investigations Of Anatomical Connectivity In The Internal Capsule Of Macaques With Diffusion Magnetic Resonance Imaging, Kyle Andrew Ignatius Taljan

ETD Archive

Understanding anatomical connectivity is crucial for improving outcomes of deep brain stimulation surgery. Tractography is a promising method for noninvasively investigating anatomical connectivity, but connections between subcortical regions have not been closely examined by this method. As many connections to subcortical regions converge at the internal capsule (IC), we investigate the connectivity through the IC to three subcortical nuclei (caudate, lentiform nucleus, and thalamus) in 6 macaques. We show that a statistical correction for a known distance-related artifact in tractography results in large changes in connectivity patterns. Our results suggest that care should be taken in using tractography to assess ...