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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Computer-Aided, Multi-Modal, And Compression Diffuse Optical Studies Of Breast Tissue, David R. Busch Jr Dec 2011

Computer-Aided, Multi-Modal, And Compression Diffuse Optical Studies Of Breast Tissue, David R. Busch Jr

Publicly Accessible Penn Dissertations

Diffuse Optical Tomography and Spectroscopy permit measurement of important physiological parameters non-invasively through ~10 cm of tissue. I have applied these techniques in measurements of human breast and breast cancer. My thesis integrates three loosely connected themes in this context: multi-modal breast cancer imaging, automated data analysis of breast cancer images, and microvascular hemodynamics of breast under compression. As per the first theme, I describe construction, testing, and the initial clinical usage of two generations of imaging systems for simultaneous diffuse optical and magnetic resonance imaging. The second project develops a statistical analysis of optical breast data from many spatial ...


Chemical And Biological Strategies For Improving The Sensitivity Of Spio-Enhanced Mr Imaging, Andrew Elias Aug 2011

Chemical And Biological Strategies For Improving The Sensitivity Of Spio-Enhanced Mr Imaging, Andrew Elias

Publicly Accessible Penn Dissertations

The prevalence of cancer has seen significant growth over the last three decades, with the American Cancer Society now reporting that one in every three Americans will be afflicted with some form of cancer in their lifetime. The debilitating effects of cancer permeate beyond obvious biological ramifications, often adversely affecting patients on emotional and financial levels as well. While significant progress has been made in diagnosing and treating cancer, advancements are still needed in detecting and treating cancers at earlier stages, where clinical outcomes will be more favorable. The field of cellular and molecular imaging has emerged as a cutting-edge ...


Indirect Detection Of Axonal Architecture With Q-Space Imaging, Henry H. Ong May 2011

Indirect Detection Of Axonal Architecture With Q-Space Imaging, Henry H. Ong

Publicly Accessible Penn Dissertations

Evaluating axon morphology would provide insights into connectivity, maturation, and disease pathology. Conventional diffusion MRI can provide metrics that are related to axon morphology, but cannot measure specific parameters such as mean axon diameter (MAD) and intracellular fraction (ICF). Q-space imaging (QSI) is an advanced diffusion MRI technique that may be able to provide more information on axon morphology. However, QSI has several limitations that affect its implementation and accuracy.

The main objective of this dissertation was to address these limitations and to evaluate the potential of QSI to accurately assess axon morphology. First, a custom-built high-amplitude gradient coil was ...


Quantitative Molecular Mri Of Intervertebral Disc Degeneration, Chenyang Wang Aug 2010

Quantitative Molecular Mri Of Intervertebral Disc Degeneration, Chenyang Wang

Publicly Accessible Penn Dissertations

Degeneration of the intervertebral disc (IVD) is the most common cause of back-related disability among North American adults. Low-back-pain and associated disability costs the United States more than 100 billion dollars annually in health care expenditures and reduced productivity. The mechanism of IVD degeneration, especially its biomolecular aspect, is poorly understood in an in vivo setting. Thus there is increasingly a need for the non-invasive diagnosis and quantification of IVD degeneration. MRI is a non-invasive imaging modality capable of producing contrast sensitive to biomolecules. Therefore, the primary objective of this dissertation research project is to develop MRI techniques capable of ...