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MRI

Musculoskeletal Diseases

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Changes In The Ultrastructural Features Of Estrogen Deficient Ovine Bone, Peter Mauer Jan 2014

Changes In The Ultrastructural Features Of Estrogen Deficient Ovine Bone, Peter Mauer

PhD theses

Osteoporosis is “a skeletal disorder characterised by compromised bone strength predis- posing to an increased risk of fracture” (NIH, 2001). Every second woman and every fifth man will suffer an osteoporotic fracture (Kanis et al., 2000). Of all people that suffer an age-related fracture, the current gold standard of osteoporosis diagnosis, DEXA scanning, misclassifies 80% of them to be non-osteoporotic (Sanders et al., 2006). Bone quantity is easily measured, however, bone strength is an interplay of bone quantity and quality — and the latter is hard to determine. More reliable clinical methods to diagnose osteoporosis are needed as well as widening ...