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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Development Of In Situ Forming Hydrogels For Intra-Articular Drug Delivery, Andy Prince Feb 2019

Development Of In Situ Forming Hydrogels For Intra-Articular Drug Delivery, Andy Prince

Electronic Thesis and Dissertation Repository

Hydrogels are 3-dimensional crosslinked polymer networks that can absorb significant amounts of water. The physical properties associated with hydrogels affords them resemblance to biological tissues making them good candidates for biomedical applications. Many pharmaceuticals, specifically non-steroidal anti-inflammatory drugs (NSAIDs), have poor aqueous solubility, which limits their bioavailability and efficacy. People suffering from chronic osteoarthritis (OA) are required to frequently take large doses to mitigate pain, which can lead to serious side effects. Hydrogels are good strategies to deliver NSAIDs via articular injection because they can form solid gels in situ. This thesis describes the synthesis, formulation, mechanical testing, in vitro ...


Novel Class Of Chronic And Implantable Wireless Optofluidic (Wof) Neural Devices For In Vivo Drug Delivery And Optogenetics In Freely Moving Animals, Raza Qazi Jan 2019

Novel Class Of Chronic And Implantable Wireless Optofluidic (Wof) Neural Devices For In Vivo Drug Delivery And Optogenetics In Freely Moving Animals, Raza Qazi

Electrical Engineering Graduate Theses & Dissertations

Chronic in-vivo studies through multimodal modulation of neurons in the deep brain can render pivotal insights not only in identifying their roles for a specific activity, but also to decipher their contribution in various neurodegenerative diseases. To prevent askew effects, probes were implanted to directly reach the target sites and the spatiotemporal resolution was further improved by targeting key neural circuits using optogenetics and pharmacology. Multimodal optofluidic probes allow integrated access to the target region without the need for multiple surgeries thus reducing tissue damage as well as simplifying combinatorial stimulations. Conventional tools have relied on rigid metal cannulas and ...