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Mechanical Engineering Graduate Theses & Dissertations

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Microbubble Size And Dose Effects On Sonoporation In Vitro And In Vivo, Kang-Ho Song Jan 2016

Microbubble Size And Dose Effects On Sonoporation In Vitro And In Vivo, Kang-Ho Song

Mechanical Engineering Graduate Theses & Dissertations

Microbubbles interact with ultrasound to induce transient microscopic pores in the cellular plasma membrane in a highly localized thermo-mechanical process called sonoporation. The objective of this study was to advance in vitro and in vivo sonoporation through the development of novel devices and methodologies to precisely characterize the effects of microbubble size on suspended cell and blood-brain barrier sonoporation. The three core findings of our study were: 1) microbubble size allows for control over sonoporation power and energy, 2) the previously cited “soft” limit on in vitro sonoporation efficiency can be overcome utilizing sequential, low-energy sonoporation with small-diameter microbubbles, and ...