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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Novel Class Of Chronic And Implantable Wireless Optofluidic (Wof) Neural Devices For In Vivo Drug Delivery And Optogenetics In Freely Moving Animals, Raza Qazi Jan 2019

Novel Class Of Chronic And Implantable Wireless Optofluidic (Wof) Neural Devices For In Vivo Drug Delivery And Optogenetics In Freely Moving Animals, Raza Qazi

Electrical Engineering Graduate Theses & Dissertations

Chronic in-vivo studies through multimodal modulation of neurons in the deep brain can render pivotal insights not only in identifying their roles for a specific activity, but also to decipher their contribution in various neurodegenerative diseases. To prevent askew effects, probes were implanted to directly reach the target sites and the spatiotemporal resolution was further improved by targeting key neural circuits using optogenetics and pharmacology. Multimodal optofluidic probes allow integrated access to the target region without the need for multiple surgeries thus reducing tissue damage as well as simplifying combinatorial stimulations. Conventional tools have relied on rigid metal cannulas and ...


Microbubble Size And Dose Effects On Sonoporation In Vitro And In Vivo, Kang-Ho Song Jan 2016

Microbubble Size And Dose Effects On Sonoporation In Vitro And In Vivo, Kang-Ho Song

Mechanical Engineering Graduate Theses & Dissertations

Microbubbles interact with ultrasound to induce transient microscopic pores in the cellular plasma membrane in a highly localized thermo-mechanical process called sonoporation. The objective of this study was to advance in vitro and in vivo sonoporation through the development of novel devices and methodologies to precisely characterize the effects of microbubble size on suspended cell and blood-brain barrier sonoporation. The three core findings of our study were: 1) microbubble size allows for control over sonoporation power and energy, 2) the previously cited “soft” limit on in vitro sonoporation efficiency can be overcome utilizing sequential, low-energy sonoporation with small-diameter microbubbles, and ...


Synthetic Peptide Design For Functionalized Hydrogels: Development Of Cellularly Responsive Drug Delivery Platforms And Cyclic, Multivalent Peptide Derivatives Using Radical-Mediated Thiol-Ene/Thiol-Yne Chemistries, Alex Arthur Aimetti Jan 2010

Synthetic Peptide Design For Functionalized Hydrogels: Development Of Cellularly Responsive Drug Delivery Platforms And Cyclic, Multivalent Peptide Derivatives Using Radical-Mediated Thiol-Ene/Thiol-Yne Chemistries, Alex Arthur Aimetti

Chemical & Biological Engineering Graduate Theses & Dissertations

Poly(ethylene glycol) (PEG)-based hydrogels represent a class of biomaterials with a growing interest for their application in numerous fields, such as drug delivery and regenerative medicine. PEG is commonly used in these applications due to its hydrophilic and bioinert properties. Additionally, peptides have been successfully incorporated within PEG hydrogels to serve as biological functionalities within a synthetic polymer platform. Peptide-functionalized PEG hydrogels have been shown to act as extracellular matrix (ECM)-mimics capable of enhancing cell survival, function, and differentiation. Alternatively, peptides can be designed to degrade in recognition of highly specific, cell-secreted proteases. This phenomenon has been ...