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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

Drug delivery

Iowa State University

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Full-Text Articles in Biomedical Engineering and Bioengineering

High Throughput Design Of Functionalized Nanoparticles For Targeted Vaccine Delivery, Ana Vianey Chavez-Santoscoy Jan 2011

High Throughput Design Of Functionalized Nanoparticles For Targeted Vaccine Delivery, Ana Vianey Chavez-Santoscoy

Graduate Theses and Dissertations

This dissertation focuses on the design of functionalized nanoparticles, a novel approach to targeted antigen delivery by decorating the surface of polyanhydride nanoparticles with specific carbohydrates to provide "pathogen-like" properties.

Polyanhydride nanoparticles are promising vaccine platforms that have the potential to be used as controlled drug delivery devices as well as potent and effective immune adjuvants for the design of single dose vaccines. CLRs offer unique advantages for tailoring immune responses. Engagement of CLRs regulates antigen presenting cell activation and promotes delivery of antigens to specific intracellular compartments inside antigen presenting cells for efficient processing and presentation.

CLRs recognize conserved ...


Engineering Amphiphillic Polyanhydride Particle Platform For Targeted Drug And Vaccine Delivery, Brenda Rocio Carrillo-Conde Jan 2011

Engineering Amphiphillic Polyanhydride Particle Platform For Targeted Drug And Vaccine Delivery, Brenda Rocio Carrillo-Conde

Graduate Theses and Dissertations

In this work, a transdisciplinary approach that combines concepts from biomaterials, nanotechnology, carbohydrate and protein chemistry, molecular biology, immunology and computational analysis has been applied to rationally design and engineer novel vaccine platforms that encompass passive and active targeting strategies.

First, the intrinsic properties of the polyanhydride systems utilized in these studies were tailored to achieve the stability of proteins with the potential to be used as antigens and/or therapeutic agents. Amphiphillic polyanhydride chemistries showed the most optimal properties to preserve structural integrity and functionality of different proteins. The surface chemistry of polyanhydride particles was also identified as an ...