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Full-Text Articles in Biomedical Engineering and Bioengineering

Fabrication And Modification Of Titania Nanotube Arrays For Harvesting Solar Energy And Drug Delivery Applications, Ahmed El Ruby Abdel Rahman Mohamed Dec 2017

Fabrication And Modification Of Titania Nanotube Arrays For Harvesting Solar Energy And Drug Delivery Applications, Ahmed El Ruby Abdel Rahman Mohamed

Electronic Thesis and Dissertation Repository

The fast diminishing of fossil fuels in the near future, as well as the global warming caused by increasing greenhouse gases have motivated the urgent quest to develop advanced materials as cost-effective photoanodes for solar light harvesting and many other photocatalytic applications. Recently, titania nanotube arrays (TNTAs) fabricated by anodization process has attracted great interest due to their excellent properties such as: high surface area, vertically oriented, highly organized, one-dimensional, nanotubular structure, photoactivity, chemical stability and biocompatibility. This unique combination of excellent properties makes TNTAs an excellent photoanode for solar light harvesting. However, the relatively wide band gap energy of ...


Synthesis And Characterization Of Poly(Simvastatin) - Incorporated Copolymers And Blends For Bone Regeneration, Theodora Asafo-Adjei Jan 2017

Synthesis And Characterization Of Poly(Simvastatin) - Incorporated Copolymers And Blends For Bone Regeneration, Theodora Asafo-Adjei

Theses and Dissertations--Biomedical Engineering

Common biodegradable polyesters such as poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA) and poly(ε-caprolactone) (PCL) are used as drug delivery vehicles for tissue regenerative applications. However, they are typically bioinert, with drug loading limitations. Polymerizing the active agent or precursor into its respective biodegradable polymer would control drug loading via molar ratios of drug to initiator used for synthesis. Simvastatin was chosen due to its favorable anti-inflammatory, angiogenic, and osteogenic properties. In addition, its lactone ring lends itself to ring-opening polymerization and, consequently, the synthesis of poly(simvastatin) with controlled simvastatin release.

Simvastatin was first polymerized with a ...


Biomimetic Oral Mucin From Polymer Micelle Networks, Sundar Prasanth Authimoolam Jan 2015

Biomimetic Oral Mucin From Polymer Micelle Networks, Sundar Prasanth Authimoolam

Theses and Dissertations--Chemical and Materials Engineering

Mucin networks are formed by the complexation of bottlebrush-like mucin glycoprotein with other small molecule glycoproteins. These glycoproteins create nanoscale strands that then arrange into a nanoporous mesh. These networks play an important role in ensuring surface hydration, lubricity and barrier protection. In order to understand the functional behavior in mucin networks, it is important to decouple their chemical and physical effects responsible for generating the fundamental property-function relationship. To achieve this goal, we propose to develop a synthetic biomimetic mucin using a layer-by-layer (LBL) deposition approach. In this work, a hierarchical 3-dimensional structures resembling natural mucin networks was generated ...


Poly(Ester Amide) And Poly(Ethyl Glyoxylate) Nanoparticles For Controlled Drug Release, Amira Mohamed Moustafa Dec 2014

Poly(Ester Amide) And Poly(Ethyl Glyoxylate) Nanoparticles For Controlled Drug Release, Amira Mohamed Moustafa

Electronic Thesis and Dissertation Repository

The objective of this research was to develop polymeric nanoparticles (NPs) having improved drug release properties for drug delivery. Poly(ester amide)s (PEAs) are promising biodegradable polymers. PEA NPs were prepared via emulsification-evaporation and salting-out methods and optimized through by varying different processing parameters. Polymer-model drug conjugates based on PEAs containing L-aspartic acid and rhodamine B were synthesized and used for NP preparation. Release behavior was studied and compared to a control system with physically encapsulated rhodamine B. It was shown that the release of rhodamine B from the covalent system did not show the burst effect and exhibited ...


High Throughput Design Of Functionalized Nanoparticles For Targeted Vaccine Delivery, Ana Vianey Chavez-Santoscoy Jan 2011

High Throughput Design Of Functionalized Nanoparticles For Targeted Vaccine Delivery, Ana Vianey Chavez-Santoscoy

Graduate Theses and Dissertations

This dissertation focuses on the design of functionalized nanoparticles, a novel approach to targeted antigen delivery by decorating the surface of polyanhydride nanoparticles with specific carbohydrates to provide "pathogen-like" properties.

Polyanhydride nanoparticles are promising vaccine platforms that have the potential to be used as controlled drug delivery devices as well as potent and effective immune adjuvants for the design of single dose vaccines. CLRs offer unique advantages for tailoring immune responses. Engagement of CLRs regulates antigen presenting cell activation and promotes delivery of antigens to specific intracellular compartments inside antigen presenting cells for efficient processing and presentation.

CLRs recognize conserved ...


Engineering Amphiphillic Polyanhydride Particle Platform For Targeted Drug And Vaccine Delivery, Brenda Rocio Carrillo-Conde Jan 2011

Engineering Amphiphillic Polyanhydride Particle Platform For Targeted Drug And Vaccine Delivery, Brenda Rocio Carrillo-Conde

Graduate Theses and Dissertations

In this work, a transdisciplinary approach that combines concepts from biomaterials, nanotechnology, carbohydrate and protein chemistry, molecular biology, immunology and computational analysis has been applied to rationally design and engineer novel vaccine platforms that encompass passive and active targeting strategies.

First, the intrinsic properties of the polyanhydride systems utilized in these studies were tailored to achieve the stability of proteins with the potential to be used as antigens and/or therapeutic agents. Amphiphillic polyanhydride chemistries showed the most optimal properties to preserve structural integrity and functionality of different proteins. The surface chemistry of polyanhydride particles was also identified as an ...


Synthetic Peptide Design For Functionalized Hydrogels: Development Of Cellularly Responsive Drug Delivery Platforms And Cyclic, Multivalent Peptide Derivatives Using Radical-Mediated Thiol-Ene/Thiol-Yne Chemistries, Alex Arthur Aimetti Jan 2010

Synthetic Peptide Design For Functionalized Hydrogels: Development Of Cellularly Responsive Drug Delivery Platforms And Cyclic, Multivalent Peptide Derivatives Using Radical-Mediated Thiol-Ene/Thiol-Yne Chemistries, Alex Arthur Aimetti

Chemical & Biological Engineering Graduate Theses & Dissertations

Poly(ethylene glycol) (PEG)-based hydrogels represent a class of biomaterials with a growing interest for their application in numerous fields, such as drug delivery and regenerative medicine. PEG is commonly used in these applications due to its hydrophilic and bioinert properties. Additionally, peptides have been successfully incorporated within PEG hydrogels to serve as biological functionalities within a synthetic polymer platform. Peptide-functionalized PEG hydrogels have been shown to act as extracellular matrix (ECM)-mimics capable of enhancing cell survival, function, and differentiation. Alternatively, peptides can be designed to degrade in recognition of highly specific, cell-secreted proteases. This phenomenon has been ...