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Full-Text Articles in Biomedical Engineering and Bioengineering
Bioengineering Approach To Understanding Tmj Pathobiology, Jonathan Kuo
Bioengineering Approach To Understanding Tmj Pathobiology, Jonathan Kuo
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The temporomandibular joint (TMJ) is a load-bearing joint consisting of the condyle of the mandibular bone, the fossa eminence of the temporal bone, and a fibrocartilaginous disc held in between the bone surfaces by ligaments. The TMJ disc serves to distribute stress, lubricate movement, and protect the articular surfaces of the joint. Over ten million Americans suffer from TMJ disorders (TMD) that affect the movement and function of the joint, making everyday tasks like talking and eating difficult and painful. A wide variety of treatments and surgeries have been proposed and undertaken with limited success based on the varying degree …
The Development Of A Mesenchymal Stem Cell Based Biphasic Osteochondral Tissue Engineered Construct, Scott Maxson
The Development Of A Mesenchymal Stem Cell Based Biphasic Osteochondral Tissue Engineered Construct, Scott Maxson
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The ability of human articular cartilage to respond to injury is poor. Once cartilage damage has occurred, an irreversible degenerative process can occur and will often lead to osteoarthritis (OA). An estimated 26.9 million of U.S. adults are affected by OA. Osteochondral grafting is currently used to treat OA and osteochondral defects; however, complications can develop at the donor site and defect area. Osteochondral tissue engineering provides a potential treatment option and alternative to osteochondral grafting. The long term goal of this work is to develop a tissue engineered mesenchymal stem cell (MSC) based osteochondral construct to repair cartilage damage. …