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Full-Text Articles in Biomedical Engineering and Bioengineering
Decitabine-Loaded Nanogel Treatment To Reverse Cancer Drug Resistance, Samantha A. Cramer
Decitabine-Loaded Nanogel Treatment To Reverse Cancer Drug Resistance, Samantha A. Cramer
ETD Archive
Cancers in which epigenetic changes, such as hypermethylation of DNA, lead to drug resistance cause the cancer to become unresponsive to existing chemotherapeutic treatments. The epigenetic drug – 5-aza-2’-deoxycytidine (decitabine, DAC) – is a potent hypomethylating agent, but its effect is transient due to its instability. Previous studies have shown that loading DAC into nanogel significantly enhances its antiproliferative effect (compared to DAC in solution) in drug-resistant breast cancer cells (MCF-7/ADR). Further, the previous studies demonstrated changes in the membrane lipid profile of resistant cells following treatment with DAC either as solution or in nanogels. The objective of the present …
Bio-Signal Analysis In Fatigue And Cancer Related Fatigue;Weakening Of Corticomuscular Functional Coupling, Qi Yang
ETD Archive
Fatigue is a common experience that reduces productivity and increases chance of injury, and has been reported as one of most common symptoms with greatest impact on quality-of-life parameters in cancer patients. Neural mechanisms behind fatigue and cancer related fatigue (CRF) are not well known. Recent research has shown dissociation between changes in brain and muscle signals during voluntary muscle fatigue, which may suggest weakening of functional corticomuscular coupling (fCMC). However, this weakening of brain-muscle coupling has never been directly evaluated. More important information could be gained if fCMC is directly detected during fatigue because a voluntary muscle contraction depends …