Biomedical Engineering and Bioengineering Commons^™

A Mathematical Model Of Cardiovascular System With Feedback Control, Jiayu Gu

Theses

A mathematical model of human cardiovascular system is presented in this study. The closed-loop model is composed of twenty compartments which includes the left and right ventricles, and the systemic and pulmonary circulations. Two physiologic feedback control mechanisms, autoregulation of blood flow and baroreceptor reflex regulation of arterial pressure, are incorporated in the model. Autoregulation acts by changing local resistance to blood flow through metabolic and myogenic mechanisms, thereby insuring a match between oxygen supply and demand for any tissue or organ. Baroreceptors act through neural pathways to alter heart rate, contractility and peripheral resistance in order to return sudden …

In Vitro Testing And Evaluation Of Intraaortic And Extraaortic Balloon Counterpulsation Devices, Joseph V. Izzo

Theses

The primary purpose of this project was to develop an in vitro environment in which the intraaortic and extra-aortic balloon pumps could be tested and evaluated. This was done by modifying a mechanical heart simulator -- the pulse duplicator system -- to accommodate both devices, and developing a software system that could collect and process the data relevant to the operation of the two balloons.

Both counterpulsation techniques were tested in the pulse duplicator where the aortic pressure and flow data were collected. The software system then processes the data to calculate all of the parameters affected by counterpulsation.

While …