Open Access. Powered by Scholars. Published by Universities.®

Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Theses/Dissertations

Biomedical

Discipline
Institution
Publication Year
Publication
File Type

Articles 1 - 23 of 23

Full-Text Articles in Biomedical Engineering and Bioengineering

Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding Aug 2019

Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding

Electronic Theses and Dissertations

Two-photon microscopy (TPM) is a powerful, versatile imaging modality for the study of biological systems. This thesis overviews the relevant physics involved in TPM, design considerations and process of constructing a home-built, two-photon microscope, and provides a set of procedures to operate the system. Furthermore, this work explores several applications of TPM through the study of single-cell metabolism and imaging the cellular-material interface. Explored in particular depth was the imaging of cellulose nanofiber (CNF) materials, with the goal of understanding the three-dimensional nature of fibroblast cell growth when embedded within the materials. This work uncovered several optical properties of CNF ...


The Effect Of Implant Conformity On Muscle Force Requirements In The Implanted Knee, Grace Mcconnochie Aug 2019

The Effect Of Implant Conformity On Muscle Force Requirements In The Implanted Knee, Grace Mcconnochie

Boise State University Theses and Dissertations

Implant geometry is a significant factor in determining knee stability and patient satisfaction following total knee replacement (TKR). Ineffective muscle recruitment, impaired joint functionality and increased implant wear are consequences of an unstable knee replacement. Current knee laxity evaluation techniques are limited in their ability to account for the muscular response to knee instability. This study utilizes a subject specific lower-body musculoskeletal finite element (FE) model with dynamic muscle loading to evaluate implant laxity during activities of daily living. The effect of varying implant conformity on the muscle forces required to maintain a target kinematic profile during simulated laxity testing ...


Flash-Mold Machine For Manufacturing Drug Implants, Conor Vache, Sonja Daebelliehn, Ryan Thomson Mar 2019

Flash-Mold Machine For Manufacturing Drug Implants, Conor Vache, Sonja Daebelliehn, Ryan Thomson

Biomedical Engineering

This Final Project Report provides the reader with a comprehensive detailing of all of the actions and work that has been completed for this Senior Design Project. In this report, the Cal Poly Biomedical Engineering Senior Project Team will discuss some background on the existing Mark I Flash-Mold Machine currently in use by Gesea Biosciences, background information on Gesea Biosciences, the Customer Requirements and Design Specifications of the new machine, Quality Engineering considerations, design concepts discussed, design concepts chosen, safety considerations, prototype development, manufacturing, testing protocols, and testing results, etc.


Hands-Free Ultrasound Transducer Attachment, Christina Harrison, Glenn Farina, Harshveer Dhaliwal Mar 2019

Hands-Free Ultrasound Transducer Attachment, Christina Harrison, Glenn Farina, Harshveer Dhaliwal

Biomedical Engineering

This document describes a background on current ultrasound technologies and the troubles that have inspired the need for a hands-free ultrasound transducer device, as well as the regulatory requirements, like patents and standard codes, for the intended invention. It also explains the Stage Gate Review process used to project plan the design of the device, a description of the final design and how it was developed, and the IQ/OQ/PQ. The objectives necessary to design this device, in order to meet all the requirements of the sponsor, are also summarized here. The design process including manufacturing instructions, prototype evolution ...


Development And Exploration Of A Z-Shaped Foot And Ankle Internal Fixation Plate, Rhaz Shaghaghi Paul, Ian Hames, Sean Rich Jan 2019

Development And Exploration Of A Z-Shaped Foot And Ankle Internal Fixation Plate, Rhaz Shaghaghi Paul, Ian Hames, Sean Rich

Williams Honors College, Honors Research Projects

This paper will detail the design process of developing a Z-shaped foot and ankle internal fixation plating system. Group 6: Plates for the Sole was made up of 5 team members, who worked together to accommodate their client’s request to complete a biomechanical analysis of a Z-Plate design and a construct a prototype. The Z-Plate’s purpose is to provide podiatrists with a new solution that can fit nicely on the small, irregular bones of the foot, while also remaining strong enough to withstand the forces and torques of the foot.


Easy Adjustable Protective Helmet, Ryan Balash Jan 2019

Easy Adjustable Protective Helmet, Ryan Balash

Williams Honors College, Honors Research Projects

Akron Children’s Hospital and The University of Akron’s Biomedical Engineering Design Team Engineering Forward have paired together to improve medical adapted helmets for post-operative and disabled patients. An issue is the helmets are only produced in a couple of sizes. Also, it is a tedious process to constantly adjust the pressure on the patient’s cranium within a trial-and-error process. Engineering Forward plans to improve the effectiveness of this helmet by creating an adjustable helmet that can read the pressure on a patient’s head. The caregiver can then make the necessary adjustments to the helmet to accommodate ...


Project "Auxilia" - Jaiden's Prosthetic Arm, Christopher Halley, Lindsay Jaros, Autumn Young Jan 2019

Project "Auxilia" - Jaiden's Prosthetic Arm, Christopher Halley, Lindsay Jaros, Autumn Young

Williams Honors College, Honors Research Projects

The main objective of this project was to create a prosthetic arm for a 15 year old boy named Jaiden Foden. Jaiden was born with only one fully developed limb as a result of a genetic disorder, Hanhart Syndrome II. His right arm becomes a residual limb below the elbow, but has two fingers which act in a “claw-like” movement. Jaiden’s left arm becomes a residual limb above the elbow, and his left leg becomes a residual limb above the knee. The goal of the arm was to increase Jaiden’s overall independence and to help in completing daily ...


The Wrist Brace Project, Nathan Nicholas Jan 2019

The Wrist Brace Project, Nathan Nicholas

Williams Honors College, Honors Research Projects

This paper outlines the engineering design process of creating a specialized wrist brace for a local child. This project was completed by a team of senior Biomedical Engineering students.


Advanced Manufacturing Of Titanium Alloys For Biomedical Applications, Nicholas C. Mavros Jan 2018

Advanced Manufacturing Of Titanium Alloys For Biomedical Applications, Nicholas C. Mavros

ETD Archive

In metallurgy, Titanium has been a staple for biomedical purposes. Its low toxicity and alloying versatility make it an attractive choice for medical applications. However, studies have shown the difference in elastic modulus between Titanium alloys (116 GPa) and human bone (40-60 GPa) contribute to long term issues with loose hardware fixation. Additionally, long term studies have shown elements such as Vanadium and Aluminum, which are commonly used in Ti-6Al-4V biomedical alloys, have been linked to neurodegenerative diseases like Alzheimers and Parkinsons. Alternative metals known to be less toxic are being explored as replacements for alloying elements in Titanium alloys ...


Development Of Spectroscopic Methods For Dynamic Cellular Level Study Of Biochemical Kinetics And Disease Progression, Anna M. Sitarski Mar 2017

Development Of Spectroscopic Methods For Dynamic Cellular Level Study Of Biochemical Kinetics And Disease Progression, Anna M. Sitarski

Electronic Theses and Dissertations

One of the current fundamental objectives in biomedical research is understanding molecular and cellular mechanisms of disease progression. Recent work in genetics support the stochastic nature of disease progression on the single cell level. For example, recent work has demonstrated that cancer as a disease state is reached after the accumulation of damages that result in genetic errors. Other diseases like Huntingtons, Parkinsons, Alzheimers, cardiovascular disease are developed over time and their cellular mechanisms of disease transition are largely unknown. Modern techniques of disease characterization are perturbative, invasive and fully destructive to biological samples. Many methods need a probe or ...


Wheelchair Fatigue Reducer, Aaron Miller, Dennis Andre Norfleet May 2016

Wheelchair Fatigue Reducer, Aaron Miller, Dennis Andre Norfleet

Chancellor’s Honors Program Projects

No abstract provided.


The Role Of Interleukin-2 In Directing Vascular Smooth Muscle Cell Function And Its Implications For Understanding The Progression Of Atherosclerosis, Prakash Arumugam Jan 2016

The Role Of Interleukin-2 In Directing Vascular Smooth Muscle Cell Function And Its Implications For Understanding The Progression Of Atherosclerosis, Prakash Arumugam

Browse all Theses and Dissertations

Atherosclerosis is an inflammatory disorder of the vasculature leading to the development of plaques within vessel walls. A critical component of atherosclerosis involves migration and proliferation of vascular smooth muscle cells (VSMCs) into the developing plaque, however, its mechanism is not yet understood. Previous studies have reported that IL-2 is deposited within the vasculature and IL-2 accumulates within atherosclerotic plaques due to secretion by infiltrating Th-1 cells. A limited number of studies suggest that VSMCs express a partial IL-2 receptor, comprising the ß and ¿ subunit. This suggests that IL-2 may elicit a physiological response in VSMCs. Considering IL-2’s proliferative ...


Detecting, Segmenting And Tracking Bio-Medical Objects, Mingzhong Li Jan 2016

Detecting, Segmenting And Tracking Bio-Medical Objects, Mingzhong Li

Doctoral Dissertations

"Studying the behavior patterns of biomedical objects helps scientists understand the underlying mechanisms. With computer vision techniques, automated monitoring can be implemented for efficient and effective analysis in biomedical studies. Promising applications have been carried out in various research topics, including insect group monitoring, malignant cell detection and segmentation, human organ segmentation and nano-particle tracking.

In general, applications of computer vision techniques in monitoring biomedical objects include the following stages: detection, segmentation and tracking. Challenges in each stage will potentially lead to unsatisfactory results of automated monitoring. These challenges include different foreground-background contrast, fast motion blur, clutter, object overlap and ...


Design And Development Of A Wearable Wireless Health Monitoring System: A Smart Watch Approach, Keerthi Paranikumar Dec 2015

Design And Development Of A Wearable Wireless Health Monitoring System: A Smart Watch Approach, Keerthi Paranikumar

Theses and Dissertations

According to Statistics, every year, about 610,000 people die because of heart disease in United States of America. (i.e. 1 in every 4 deaths.*) Heart disease is common for both men and women. Annually, about 370,000 people die because of coronary heart disease, which is the most common type of heart disease [1]. About 735,000 Americans have heart attack every year. In this, 210,000 people gets heart attack who already has heart problems and 525,000 people get heart attack for the first time [2]. Not many people know that they have heart problems. Around ...


Fiber Optic Bandage, Logan Mcneil May 2015

Fiber Optic Bandage, Logan Mcneil

Chancellor’s Honors Program Projects

No abstract provided.


Multichannel Characterization Of Brain Activity In Neurological Impairments, Yalda Shahriari Apr 2015

Multichannel Characterization Of Brain Activity In Neurological Impairments, Yalda Shahriari

Biomedical Engineering Theses & Dissertations

Hundreds of millions of people worldwide suffer from various neurological and psychiatric disorders. A better understanding of the underlying neurophysiology and mechanisms for these disorders can lead to improved diagnostic techniques and treatments. The objective of this dissertation is to create a novel characterization of multichannel EEG activity for selected neurological and psychiatric disorders based on available datasets. Specifically, this work provides spatial, spectral, and temporal characterizations of brain activity differences between patients/animal models and healthy controls, with focus on modern techniques that quantify cortical connectivity, which is widely believed to be abnormal in such disorders. Exploring the functional ...


Foley Catheter Priming Device, Melissa A. Boswell, Landon Davis, Renee Horn, Tyler Grubb, Jason Green Jan 2015

Foley Catheter Priming Device, Melissa A. Boswell, Landon Davis, Renee Horn, Tyler Grubb, Jason Green

Williams Honors College, Honors Research Projects

A lack of a pressure gradient throughout the catheter prevents urine flow from the bladder and through catheter system in a condition referred to as “air-lock.” The purpose of this project was to design a device that could be utilized by person with a catheter faced with the problem of air-lock to restore urine flow and normal functioning of the catheter system. After a prototype was created, the device was put through a series of tests to insure proper functioning, absence of leakage, and durability. The device created can be added in-line with the catheter system, inconspicuously under the user ...


Power Soccer Footguard Attachment System, Allison Hubbell, Vivian Kontoveros, Andrew Mcclain, Lauren Monsanty Jan 2015

Power Soccer Footguard Attachment System, Allison Hubbell, Vivian Kontoveros, Andrew Mcclain, Lauren Monsanty

Williams Honors College, Honors Research Projects

The purpose of this research project was to develop a new method of attaching a footguard to the front of a power wheelchair to be used in the adaptive sport, power soccer. Completion of this project was requested by Adaptive Sports Program of Ohio (A.S.P.O.). It was requested that Limitless Sports Solutions, a team of Biomedical Engineering students, create a new design which would be more efficient, have less moving parts, and be easier to attach overall than the system currently being used by A.S.P.O. During the scope of this project, research was conducted ...


Modeling, Analysis, And Control Of A Mobile Robot For In Vivo Fluoroscopy Of Human Joints During Natural Movements, Matthew A. Young May 2014

Modeling, Analysis, And Control Of A Mobile Robot For In Vivo Fluoroscopy Of Human Joints During Natural Movements, Matthew A. Young

Doctoral Dissertations

In this dissertation, the modeling, analysis and control of a multi-degree of freedom (mdof) robotic fluoroscope was investigated. A prototype robotic fluoroscope exists, and consists of a 3 dof mobile platform with two 2 dof Cartesian manipulators mounted symmetrically on opposite sides of the platform. One Cartesian manipulator positions the x-ray generator and the other Cartesian manipulator positions the x-ray imaging device. The robotic fluoroscope is used to x-ray skeletal joints of interest of human subjects performing natural movement activities. In order to collect the data, the Cartesian manipulators must keep the x-ray generation and imaging devices accurately aligned while ...


Development And Experimental Analysis Of Wireless High Accuracy Ultra-Wideband Localization Systems For Indoor Medical Applications, Michael Joseph Kuhn May 2012

Development And Experimental Analysis Of Wireless High Accuracy Ultra-Wideband Localization Systems For Indoor Medical Applications, Michael Joseph Kuhn

Doctoral Dissertations

This dissertation addresses several interesting and relevant problems in the field of wireless technologies applied to medical applications and specifically problems related to ultra-wideband high accuracy localization for use in the operating room. This research is cross disciplinary in nature and fundamentally builds upon microwave engineering, software engineering, systems engineering, and biomedical engineering. A good portion of this work has been published in peer reviewed microwave engineering and biomedical engineering conferences and journals. Wireless technologies in medicine are discussed with focus on ultra-wideband positioning in orthopedic surgical navigation. Characterization of the operating room as a medium for ultra-wideband signal transmission ...


Methods Development And Force Field Evaluation For Molecular Simulations Of Iinteractions Between Structured Peptides And Functionalized Material Surfaces, Galen Collier May 2011

Methods Development And Force Field Evaluation For Molecular Simulations Of Iinteractions Between Structured Peptides And Functionalized Material Surfaces, Galen Collier

All Dissertations

The process of protein adsorption to material surfaces is highly complex and it is one of the most fundamental concepts upon which progress in the field of bioengineering is based. The strategic design of material surfaces for optimal utility in specific biological environments is absolutely dependent upon a thorough understanding of the mechanisms underlying protein adsorption, yet there is still a very limited understanding of these mechanisms. The primary reason for this lack of understanding is that protein adsorption is a dynamic process which occurs at the atomic and macromolecular scale, where experimental analyses provide a view that is static ...


Development Of Software To Estimate Pressures On The Residual Limbs Of Amputees By Means Of A Pylon Mounted Transducer, Malli K. Yalamanchili Dec 2010

Development Of Software To Estimate Pressures On The Residual Limbs Of Amputees By Means Of A Pylon Mounted Transducer, Malli K. Yalamanchili

UNLV Theses, Dissertations, Professional Papers, and Capstones

The alignment of prosthesis has been recognized as one of the main factors that determine successful prosthetic outcomes for trans-tibial amputees. Alignment is defined as the relative position and orientation of the prosthetic components. Misalignment can result in changes in the position and orientation of the joints of the leg and moments experienced by them during gait, increases in energy use, and discomfort or even tissue breakdown at the socket/stump interface. Hence it is very important to align the prosthesis in correct manner. Gait analysis can be used to examine the effects of incorrect alignment of the prosthesis during ...


Synthesis And Characterization Of Diamond-Like Carbon Thin Films For Biomedical Applications, Russell Lee Leonard Dec 2010

Synthesis And Characterization Of Diamond-Like Carbon Thin Films For Biomedical Applications, Russell Lee Leonard

Masters Theses

Diamond-like carbon (DLC) thin films were produced by pulsed laser deposition (PLD) on silicon, fused silica, and silicon nitride substrates. The films produced were either undoped, made using a pure graphite target, or doped, using multi-component targets made from a combination of graphite and silicon, silicon nitride, titanium dioxide, or silicon monoxide. These films were evaluated for their potential use in biomedical applications, including coatings for artificial joints, heart stents, and bronchoscopes. The films were characterized by Raman spectroscopy, atomic force microscopy, ball-on-flat tribometry, contact angle measurements, and spectrophotometry. Film thickness was determined by optical profilometry. Film adhesion was checked ...