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Biomaterials

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Full-Text Articles in Biomedical Engineering and Bioengineering

Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding Aug 2019

Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding

Electronic Theses and Dissertations

Two-photon microscopy (TPM) is a powerful, versatile imaging modality for the study of biological systems. This thesis overviews the relevant physics involved in TPM, design considerations and process of constructing a home-built, two-photon microscope, and provides a set of procedures to operate the system. Furthermore, this work explores several applications of TPM through the study of single-cell metabolism and imaging the cellular-material interface. Explored in particular depth was the imaging of cellulose nanofiber (CNF) materials, with the goal of understanding the three-dimensional nature of fibroblast cell growth when embedded within the materials. This work uncovered several optical properties of CNF ...


Investigation Of The Effect Of Age On Regenerative Outcomes Following Treatment Of Volumetric Muscle Loss Injuries, John Taehwan Kim Aug 2019

Investigation Of The Effect Of Age On Regenerative Outcomes Following Treatment Of Volumetric Muscle Loss Injuries, John Taehwan Kim

Theses and Dissertations

Volumetric muscle loss (VML) is a traumatic injury in skeletal muscle resulting in the bulk loss of more than 20% of the muscle’s volume. Included in the bulk loss of muscle is the skeletal muscle niche comprised of nerve bundles, vasculature, local progenitor cells, basal lamina, and muscle fibers, overwhelming innate repair mechanisms. The hallmark of VML injury is the excessive accumulation of non-contractile, fibrotic tissue and permanent functional deficits. Though predominant in the younger demographic, the elderly population is also captured within VML injuries. There are many factors that change with aging in skeletal muscle that may further ...


Two And Three-Dimensional Models For Material And Cells Interaction, Nam H. Nguyen May 2019

Two And Three-Dimensional Models For Material And Cells Interaction, Nam H. Nguyen

Doctoral Dissertations

Three-dimensional (3D) cell spheroid model has been long considered a better model to mimic in vivo physiology compared to two-dimensional (2D) cell culture model. Traditional 2D cell models provide a simple, convenient and quick technique for drug screening but fail to simulate the complexity and heterogeneity of cells in the in vivo environment. The last few decades have remarked substantial progress toward the advancement of three-dimensional (3D) cell cultures as systems which better mimic cellcell and cell-matrix interaction in the in vivo physiology. Nowadays, 3D cell models have been emerging, not only as an important approach in drug discovery and ...


Improved Orthopaedic Repairs Through Mechanically Optimized, Adhesive Biomaterials, Stephen Wheeler Linderman May 2019

Improved Orthopaedic Repairs Through Mechanically Optimized, Adhesive Biomaterials, Stephen Wheeler Linderman

Engineering and Applied Science Theses & Dissertations

Despite countless surgical advances over the last several decades refining surgical approaches, repair techniques, and tools to treat tendon and tendon-to-bone injuries, we are still left with repair solutions that rely on fairly crude underlying mechanical principles. Musculoskeletal soft tissues have evolved to transfer high loads by optimizing stress distribution profiles across the tissue at each length scale. However, instead of mimicking these natural load transfer mechanisms, conventional suture approaches are limited by high load transfer across only a small number of anchor points within tissue. This leads to stress concentrations at anchor points that often cause repair failure as ...


Biodegradable And Biocompatible Silk Fibroin For Optical Applications, Corey Bryce Malinowski Dec 2018

Biodegradable And Biocompatible Silk Fibroin For Optical Applications, Corey Bryce Malinowski

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study presents nanopatterned silk fibroin films that were fabricated using soft lithography and nanoimprinting to replicate patterns from diffraction gratings. These film’s optics were analyzed based on their light scattering potential as well as their transmittance and transmission haze using a laser light, spectrometer, and UV-Vis spectrophotometer, respectively. The patterned fibroin films all displayed similar light scattering patterns to their master patterns with some transmission haze. When using the spectrometer to measure samples, those made without any nanostructure displayed transmission of 90% and over, while those with patterns depended on the structure used. The denser a structure, like ...


Determining The Effect Of Locally Delivered Bioactive Modulators On Macrophage Activation At The Implantation Site Of Different Biomaterials In Rats, Kamel Alkhatib Aug 2018

Determining The Effect Of Locally Delivered Bioactive Modulators On Macrophage Activation At The Implantation Site Of Different Biomaterials In Rats, Kamel Alkhatib

Theses and Dissertations

Altering the foreign body reaction by targeting macrophages has been of interest in the biomaterials field to improve the integration of longevity of implanted biomedical devices. The objective of this dissertation was to study the effect of locally delivered bioactive modulators on macrophage activation at the implantation site of different biomaterials in rats. Iloprost, a prostacyclin analog, was tested for its ability to direct macrophages to their pro-wound healing phenotype after the implantation of microdialysis probe in the subcutaneous space of male Sprague Dawley rats. This study showed that iloprost can shift macrophage activation states in vivo to the pro-wound ...


Investigating Biomaterial-Based Biophysical Cues For Modulating Macrophage Polarization Towards Bone Regeneration Applications, Rukmani Sridharan Jul 2018

Investigating Biomaterial-Based Biophysical Cues For Modulating Macrophage Polarization Towards Bone Regeneration Applications, Rukmani Sridharan

PhD theses

As one of the first cells to respond to biomaterial implantation, macrophages, through polarization into pro- (M1) and anti-inflammatory (M2) states, secrete cytokines and chemokines that determine the subsequent immune response and eventual success of an implanted biomaterial. Little is known about how biomaterial properties, especially biophysical cues, modulate the macrophage response and their interaction with mesenchymal stem cells (MSCs), another important cell type in the implant environment. The overall objective of the research presented in this thesis was to understand the role of biophysical cues presented by biomaterials in directing macrophage polarization, function, migration and interaction with MSCs, and ...


Biophysical Features Of The Extracellular Matrix Direct Breast Cancer Metastasis, Alyssa Schwartz Jan 2018

Biophysical Features Of The Extracellular Matrix Direct Breast Cancer Metastasis, Alyssa Schwartz

Doctoral Dissertations

Breast cancer is plagued by two key clinical challenges; drug resistance and metastasis. Most work to date probes these events on an extremely rigid plastic surface, which recapitulates few aspects of these processes in humans. A malignant cell first resides in breast tissue, then likely travels to the bone, brain, liver, or lung, each of which has a distinct mechanical and biochemical profile. Cells transmit mechanical forces into intracellular tension and biochemical signaling events, and here we hypothesize that this mechanotransduction influences drug response, growth, and migration.

To probe the impact of extracellular matrix on drug resistance, we defined a ...


The Efficacy Of Bionate As An Articulating Surface For Joint Hemiarthroplasty, Sarah Dedecker Dec 2016

The Efficacy Of Bionate As An Articulating Surface For Joint Hemiarthroplasty, Sarah Dedecker

Electronic Thesis and Dissertation Repository

Hemiarthroplasty procedures replace the diseased side of the joint with an implant to maximize bone preservation while maintaining more native anatomy than a total joint replacement. Even though hemiarthroplasty procedures have been clinically successful, they cause progressive cartilage damage over time due to the use of relatively stiff metallic implant materials. This work investigates the role of low moduli implant material on implant-cartilage contact mechanics and early in vitro cartilage wear. A finite element simulation was developed to assess the effect of low moduli implants in the range of 0.015-0.288 GPa on contact mechanics. Higher contact area and ...


Enabling Studies To Optimize Biomaterials For The Treatment Of Myocardial Infarction, Eva Adriana Romito Jun 2016

Enabling Studies To Optimize Biomaterials For The Treatment Of Myocardial Infarction, Eva Adriana Romito

Theses and Dissertations

The canonical mechanism of wound healing is disrupted following a myocardial infarction (MI), manifesting as an unregulated response that negatively impacts left ventricular (LV) function. This mechanism, termed post-MI remodeling, culminates in an outcome that favors progression to a systolic heart failure state and death for the patient. Therapeutic approaches following the occurrence of a MI are designed to modulate the natural remodeling process and mitigate the loss of cardiac function. The mechanics and structure of the healing infarct have been the focus of numerous pre-clinical and clinical investigations, leading to the impending clinical introduction of material injections as a ...


Elastin Like Polypeptides As Drug Delivery Vehicles In Regenerative Medicine Applications, Alex Leonard Mar 2016

Elastin Like Polypeptides As Drug Delivery Vehicles In Regenerative Medicine Applications, Alex Leonard

Graduate Theses and Dissertations

Elastin like polypeptides (ELPs) are a class of naturally derived biomaterials that are non-immunogenic, genetically encodable, and biocompatible making them ideal for a variety of biomedical applications, ranging from drug delivery to tissue engineering. Also, ELPs undergo temperature-mediated inverse phase transitioning, which allows them to be purified in a relatively simple manner from bacterial expression hosts. Being able to genetically encode ELPs allows for the incorporation of bioactive peptides and functionalization of ELPs. This work utilizes ELPs for regenerative medicine and drug delivery.

The goal of the first study was to synthesize a biologically active epidermal growth factor-ELP (EGF-ELP) fusion ...


Bioactive Poly(Beta-Amino Ester) Biomaterials For Treatment Of Infection And Oxidative Stress, Andrew L. Lakes Jan 2016

Bioactive Poly(Beta-Amino Ester) Biomaterials For Treatment Of Infection And Oxidative Stress, Andrew L. Lakes

Theses and Dissertations--Chemical and Materials Engineering

Polymers have deep roots as drug delivery tools, and are widely used in clinical to private settings. Currently, however, numerous traditional therapies exist which may be improved through use of polymeric biomaterials. Through our work with infectious and oxidative stress disease prevention and treatment, we aimed to develop application driven, enhanced therapies utilizing new classes of polymers synthesized in-house. Applying biodegradable poly(β-amino ester) (PBAE) polymers, covalent-addition of bioactive substrates to these PBAEs avoided certain pitfalls of free-loaded and non-degradable drug delivery systems. Further, through variation of polymer ingredients and conditions, we were able to tune degradation rates, release profiles ...


Effect Of Hemiarthroplasty Implant Contact Geometry And Material On Early Cartilage Wear, Alana Khayat Sep 2015

Effect Of Hemiarthroplasty Implant Contact Geometry And Material On Early Cartilage Wear, Alana Khayat

Electronic Thesis and Dissertation Repository

Hemiarthroplasty is a minimally invasive, cost-effective alternative to total arthroplasty in joints of the upper limb. Though these procedures reduce patient morbidity while restoring joint kinematics, their longevity is limited by wear of the adjacent cartilage. This work investigates the roles of contact geometry and implant stiffness on cartilage wear with the aim of elucidating the mechanics that contribute to cartilage damage. An in vitro study examined the influence of implant geometry on cartilage wear using a pin-on-plate wear simulator. A significant decrease in volumetric wear was observed as contact area increased, which suggests that maximizing contact area should be ...


Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague Aug 2015

Biodegradable Nano-Hybrid Polymer Composite Networks For Regulating Cellular Behavior, Charles Henley Sprague

Masters Theses

Photo-crosslinkable polymeric biomaterials have emerged in the field of biomedical research to promote tissue regeneration. For example, scaffolds that can be crosslinked and hardened in situ have been known to make suitable implant alternatives. Since injectable and photo-crosslinkable biomaterials offer the advantage of being minimally invasive, they have emerged to compete with autografts, a current highly invasive method to repair diseased tissue. A series of novel photo-crosslinkable, injectable, and biodegradable nano-hybrid polymers consisting of poly(ε-caprolactone fumarate) (PCLF) and polyhedral oligomeric silsesquioxane (POSS) has been synthesized in our laboratory via polycondensation. To engineer the material properties of the nano-hybrid networks ...


Nano Scale Mechanical Analysis Of Biomaterials Using Atomic Force Microscopy, Diganta Dutta Jul 2015

Nano Scale Mechanical Analysis Of Biomaterials Using Atomic Force Microscopy, Diganta Dutta

Mechanical & Aerospace Engineering Theses & Dissertations

The atomic force microscope (AFM) is a probe-based microscope that uses nanoscale and structural imaging where high resolution is desired. AFM has also been used in mechanical, electrical, and thermal engineering applications. This unique technique provides vital local material properties like the modulus of elasticity, hardness, surface potential, Hamaker constant, and the surface charge density from force versus displacement curve. Therefore, AFM was used to measure both the diameter and mechanical properties of the collagen nanostraws in human costal cartilage. Human costal cartilage forms a bridge between the sternum and bony ribs. The chest wall of some humans is deformed ...


The Role Of Matrix Properties In Directing Valvular Interstitial Cell Phenotype, Kelly Marie Pollock Mabry Jan 2015

The Role Of Matrix Properties In Directing Valvular Interstitial Cell Phenotype, Kelly Marie Pollock Mabry

Chemical & Biological Engineering Graduate Theses & Dissertations

This thesis presents the development of hydrogel platforms to study the fibroblast-to-myofibroblast transition in valvular interstitial cells (VICs). These systems were used to characterize the effects of extracellular matrix cues on VICs, as well as the synergies between mechanical and biochemical signals. First, the impact of culture platform on VIC phenotype was assessed by culturing VICs in peptide-functionalized poly(ethylene glycol) hydrogels (2D and 3D) and comparing them to those cultured on tissue culture polystyrene (TCPS). Expression of the myofibroblast marker α-smooth muscle actin (αSMA), as well as by a global analysis of the transcriptional profiles1 demonstrated that TCPS ...


A Rubric For Electrochemical Testing Of Metallic Biomaterials, Frederick G. De La Fuente Aug 2014

A Rubric For Electrochemical Testing Of Metallic Biomaterials, Frederick G. De La Fuente

Master's Theses and Project Reports

Corrosion is a major factor for the failure of metallic medical implants. Testing a metal’s suseptability to corrosion prior to implantation is key to a successful implantation. Electrochemical processes were used in this study to evaluate the characteristics of corrosion of both AISI 316 stainless steel and titanium alloy Ti6Al4V, welded and non-welded. Linear, potentiodynamic, and cyclic polarization curves were produced by the PARC 2273 potentiostat showing the corrosion tendencies of the metals in four unique solutions 3.5% NaCl, 0.35% NaCl, phosphate buffered saline solution (PBS), and Butterfield phosphate buffered solution (BPS). The concentration of chloride ions ...


Functional Co-Substituted Poly[(Amino Acid Ester)Phosphazene] Biomaterials, Amanda L. Baillargeon Jul 2014

Functional Co-Substituted Poly[(Amino Acid Ester)Phosphazene] Biomaterials, Amanda L. Baillargeon

Electronic Thesis and Dissertation Repository

The development of new and improved biomaterials is essential for tissue engineering and regenerative medicine applications. Amino acid-based polyphosphazenes are being explored as scaffold materials for tissue engineering applications due to their non-toxic degradation products and tunable material properties. This work focuses on the synthesis of non-functional and novel functional poly[(amino acid ester)phosphazene]s using a facile method of thermal ring opening polymerization followed by one-pot room temperature substitution. The family of polyphosphazenes developed in this work is based on L-alanine (PNEAs), L-phenylalanine (PNEFs), and L-methionine (PNEMs) with L-glutamic acid imparting the functionality. Characterization of these materials demonstrated ...


Sic For Advanced Biological Applications, Joseph Register Mar 2014

Sic For Advanced Biological Applications, Joseph Register

Graduate Theses and Dissertations

Silicon carbide (SiC) has been used for centuries as an industrial abrasive and has been

actively researched since the 1960's as a robust material for power electronic applications.

Despite being the first semiconductor to emit blue light in 1907, it has only recently been

discovered that the material has crucial properties ideal for long-term, implantable biomedical

devices. This is due to the fact that the material offers superior biocompatibility and

hemocompatibility while providing rigid mechanical and chemical stability. In addition, the material

is a wide-bandgap semiconductor that can be used for optoelectronics, light delivery, and optical

sensors, which is ...


Process Extension From Embryonic Stem Cell-Derived Motor Neurons Through Synthetic Extracellular Matrix Mimics, Daniel Devaud Mckinnon Jan 2014

Process Extension From Embryonic Stem Cell-Derived Motor Neurons Through Synthetic Extracellular Matrix Mimics, Daniel Devaud Mckinnon

Chemical & Biological Engineering Graduate Theses & Dissertations

This thesis focuses on studying the extension of motor axons through synthetic poly(ethylene glycol) PEG hydrogels that have been modified with biochemical functionalities to render them more biologically relevant. Specifically, the research strategy is to encapsulate embryonic stem cell-derived motor neurons (ESMNs) in synthetic PEG hydrogels crosslinked through three different chemistries providing three mechanisms for dynamically tuning material properties. First, a covalently crosslinked, enzymatically degradable hydrogel is developed and exploited to study the biophysical dynamics of axon extension and matrix remodeling. It is demonstrated that dispersed motor neurons require a battery of adhesive peptides and growth factors to maintain ...


Scratch Damage Evolution On Metals In Total Joint Replacements, Caleb Eljach Dec 2013

Scratch Damage Evolution On Metals In Total Joint Replacements, Caleb Eljach

All Theses

The goal of total joint replacement (TJR) is to replace nonfunctioning joint components and relieve pain, improve quality of life, and to improve joint function. Although TJR is a successful procedure, more than 54,000 knee revisions occur each year due to factors, such as wear, loosening, infection, fracture, instability, and patient related factors (Ranawat, 2010). TJRs consist of components typically composed of polyethylene and a metallic counterface (Navarro, 2008). The sliding contact that occurs between the metal and polyethylene components has been well studied and is shown to produce both surface damage and wear of the implant components (Barbour ...


Implantable Biosensors For Physiologic Status Monitoring During Hemorrhage, Christian Kotanen Aug 2013

Implantable Biosensors For Physiologic Status Monitoring During Hemorrhage, Christian Kotanen

All Dissertations

Trauma diagnostics and management are major aims of research for implantable amperometric enzyme biosensor technology. Biosensors are capable of monitoring metabolic variables in a minimally invasive manner and have great potential to augment current wireless vital sign monitoring technologies in order to make a more robust physiologic status monitoring platform. The dual responsive Electrochemical Cell-on-a-Chip Microdisc Electrode Array (ECC MDEA 5037) is a recently developed electrochemical transducer for use in a wireless, implantable biosensor system for the continuous measurement of interstitial glucose and lactate. Hyperglycemia arising from insulin resistance and hyperlactatemia arising from anaerobic metabolism both occur following trauma and ...


Fabricating And Characterizing Physical Properties Of Electrospun Polypeptide-Based Nanofibers, Dhan Bahadur Khadka Jan 2013

Fabricating And Characterizing Physical Properties Of Electrospun Polypeptide-Based Nanofibers, Dhan Bahadur Khadka

Graduate Theses and Dissertations

This dissertation has aimed to fabricate polypeptide based biomaterial and characterize physical properties. Electrospinning is used as a tool for the sample fabrication. Project focused on determining the feasibility of electrospinning of certain synthetic polypeptides and certain elastin-like peptides from aqueous feedstocks and to characterize physical properties of polymer aqueous solution, cast film and spun fibers and fiber mats. The research involves peptide design, polymer electrospinning, fibers crosslinking, determining the extent of crosslinking, fibers protease degradation study, fibers stability and self-organization analysis, structure and composition determination by various spectroscopy and microscopy techniques and characterization of mechanical properties of individual suspended ...


Calcium Phosphate-Based Resorbable Biomaterials For Bone Regeneration, Daniel O. Costa Oct 2012

Calcium Phosphate-Based Resorbable Biomaterials For Bone Regeneration, Daniel O. Costa

Electronic Thesis and Dissertation Repository

Bone defects are a prevalent problem in orthopedics and dentistry. Calcium phosphate-based coatings and nanocomposites offer unique solutions towards producing scaffolds with suitable physical, mechanical and biological properties for bone regeneration.

We developed a novel method to synthesize hydroxyapatite (HA) particles with high aspect ratio using sol-gel chemistry and hydrothermal treatment. We obtained tunable pure-phase carbonated-HA in the form of micro/nanorods and nanowires (diameters 25-800 nm). To mimic the structure of bone, HA nanowires were homogenously mixed within poly(ε-caprolactone) (PCL) to produce nanocomposites with improved mechanical properties as determined by uniaxial tensile testing.

Surface chemistry and topography of ...


Development And Characterization Of Plga And Eptfe Blood Vessel Mimics Using Gene Expression Analysis, Michael Gibbons, Sarah Ur Jun 2012

Development And Characterization Of Plga And Eptfe Blood Vessel Mimics Using Gene Expression Analysis, Michael Gibbons, Sarah Ur

Biomedical Engineering

Tissue engineered blood vessels (TEBV’s) have the potential to act not only as a replacement for diseased vessels, but also as a testing platform for intravascular devices such as stents. To this end, the goal of this study was to develop protocols for the construction of TEBV’s composed of human vascular cells and either expanded polytetrafluoroethylene (ePTFE) or poly-lactic-co-glycolic acid (PLGA), as well as a protocol for gene expression in those TEBV’s. Initial experiments involved only human umbilical vein endothelial cells (HUVEC’s), but after low cell confluency and spreading in single-sodded vessels a second cell type ...


Engineering Of Polyamidoamine (Pamam) Dendrimers For Gene And Drug Delivery, Quan Yuan Apr 2012

Engineering Of Polyamidoamine (Pamam) Dendrimers For Gene And Drug Delivery, Quan Yuan

Theses and Dissertations

Dendrimers are a class of polymers with a highly branched, three-dimensional architecture composed of an initiator core, several interior layers of repeating units and multiple surface groups. They have been recognized as the most versatile compositionally and structurally controlled nanoscale building blocks throughout the fields of engineering, materials science, chemistry, and biology, and they have been widely investigated for drug and gene delivery. Polyamidoamine (PAMAM) dendrimers have inherent properties for gene delivery because of their high buffering capacity, polycationic surface and numerous surface groups for biofunctionlization. This dissertation is organized into four independent sections. The first section investigates a series ...


Cell Adhesion And Migration On Ndga Cross-Linked Fibrillar Collagen Matrices For Tendon Tissue Engineering, Ana Ysabel Rioja Jan 2012

Cell Adhesion And Migration On Ndga Cross-Linked Fibrillar Collagen Matrices For Tendon Tissue Engineering, Ana Ysabel Rioja

Graduate Theses and Dissertations

Tendons, essential tissues that connect muscles to bones, are susceptible to rupture/degeneration due to their continuous use for enabling movement. Often surgical intervention is required to repair the tendon; relieving the pain and fixing the limited mobility that occurs from the damage. Unfortunately, post-surgery immobilization techniques required to restore tendon properties frequently lead to scar formation and reduced tendon range of motion. Our ultimate goal is to create an optimal tendon prosthetic that can stabilize the damaged muscle-bone connection and then be remodeled by resident cells from the surrounding tissues over time to ensure long-term function. To achieve this ...


Improved Manufacturing Methods Of Bovine Femur Samples For Ultrasonic Testing And Assessment Of Materials Through Contract Angle Measurement, Kevin Mathew Lopez Galang Sep 2011

Improved Manufacturing Methods Of Bovine Femur Samples For Ultrasonic Testing And Assessment Of Materials Through Contract Angle Measurement, Kevin Mathew Lopez Galang

Biomedical Engineering

At California Polytechnic State University of San Luis Obispo (Cal Poly), the Biomedical Engineering department (BMED) requires its students to take the course listed as “BMED 420: Principles of Biomaterial Designs.” BMED 420 has a required laboratory section every week throughout the duration of the course that is meant to be a supplemental tool for learning. During the lab sections, students perform experiments and exercises that are currently being implemented in the industry. Despite accuracy of the methods and experiments relative to their use in the industry, there is always room for improvement. The objective of this project will illustrate ...


Evaluation Of Factors That Modulate Cellular Adipogenesis For Breast Tissue Engineering Strategies, Cheryl Gomillion Dec 2010

Evaluation Of Factors That Modulate Cellular Adipogenesis For Breast Tissue Engineering Strategies, Cheryl Gomillion

All Dissertations

It is estimated that this year more than 200,000 women in the United States will be diagnosed with breast cancer. Treatment for most occurrences of breast cancer will often include surgical removal of the tumorigenic tissue, resulting in a soft tissue defect within the subcutaneous tissue of the skin. Post-surgical reconstruction methods are often sought by patients to restore the aesthetic function of the breast via cellular or non-cellular methods; however, because of complications associated with currently used methods for breast reconstruction, researchers are investigating tissue engineering methods to produce viable autologous adipose tissue for breast reconstruction.
Previous research ...


Acellular And Radically Polymerized Biodegradable Materials To Control Tissue Interactions After Myocardial Infarction, Jamie L. Ifkovits Aug 2010

Acellular And Radically Polymerized Biodegradable Materials To Control Tissue Interactions After Myocardial Infarction, Jamie L. Ifkovits

Publicly Accessible Penn Dissertations

Left ventricular remodeling following myocardial infarction (MI) often induces congestive heart failure, which has limited treatment options. Advances in tissue engineering and polymer chemistry, however have allowed for the development of alternative treatment strategies. Specifically, the formation of biodegradable polymers into complex scaffolds or injectable materials is being evaluated. The underlying hypothesis for this work is that fibrous scaffolds with controlled properties and structures, as well as injectable hydrogels with tunable properties, can be optimized to attenuate this post-MI remodeling response. To this end, four specific aims have been developed to test this global hypothesis.

First, a collection of biodegradable ...