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Full-Text Articles in Biomedical Engineering and Bioengineering
Development Of Collagen-Based Scaffolds For Differentiation Of Induced Pluripotent Stem Cells, Siteng Fang
Development Of Collagen-Based Scaffolds For Differentiation Of Induced Pluripotent Stem Cells, Siteng Fang
Graduate Dissertations and Theses
Collagen hydrogel has been broadly studied and applied in engineering 3D scaffold materials in tissue engineering. A collagen hydrogel can provide cells with a porous and soft environment to proliferate and differentiate. However, lacking mechanical stiffness and shrinkage resistance made it a challenge to sustain shape and size during a long stem cell differentiation process. In addition, a cytocompatible scaffold for human induced pluripotent stem cell (iPSC)-laden culture has not been fully investigated. The goal of this study is to develop stable and biocompatible collagen-based scaffolds that are suitable for direct seeding and lineage progression of iPSCs. In this work, …
Fibers For Skin Regeneration, Astrid Michelle Rodriguez Negron
Fibers For Skin Regeneration, Astrid Michelle Rodriguez Negron
Theses and Dissertations
This thesis presents the successful development of biocompatible Polyvinyl Butyral (PVB), PVB/Polylysine and PVB/Tannic Acid (TA)/Polylysine fibers from an ethanol solution, Polyhydroxybutyrate (PHB), PHB/Polylysine, PHB/TA/Polylysine fibers from a chloroform solution and Chitosan (CH)/Pullulan (PL)/TA and CH/PL/TA/Polylysine fibers from an aqueous solution. The fibers were mass produced utilizing the Forcespinning® (FS) technology. The morphology of the fibers was characterized using a scanning electron microscope (SEM) and the fibers average diameter was calculated. The thermal properties of the fibers were characterized using a thermogravimetric analyzer (TGA) and a differential scanning calorimeter (DSC). The antibacterial activity of the fibers was assessed using against …