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Full-Text Articles in Biomedical Engineering and Bioengineering
Efficacy Of Eluted Antibiotics In 3d Printed Orthopaedic Implants, Mohammed Mehdi Benmassaoud
Efficacy Of Eluted Antibiotics In 3d Printed Orthopaedic Implants, Mohammed Mehdi Benmassaoud
Theses and Dissertations
Costs associated with musculoskeletal diseases in the United States account for 5.7 % of the Gross Domestic Product (GDP) [1]. As such, there is a need to pursue new ideas in orthopaedic implants that can decrease cost and improve patient care. In the recent years, 3D printing using Fused Deposition Modeling (FDM) or Stereolithography (SLA) has opened several exciting possibilities to create orthopaedic implants. Such implants can be engineered to release antibiotics in a controlled manner either by infusing the drug into the material during manufacturing or by using built-in design features such as micro-channels and reservoirs [2]. The use …
Kinematic Analysis Of Spinal Cord Injury Animals Treated With A Neurotrophin-Infused Scaffold And Body Weight Supported Treadmill Training, Alexander Herman
Kinematic Analysis Of Spinal Cord Injury Animals Treated With A Neurotrophin-Infused Scaffold And Body Weight Supported Treadmill Training, Alexander Herman
Theses and Dissertations
Spinal Cord Injury (SCI) is a condition that affects around 250,000 Americans with no cure. Existing treatments rely on physical therapies such as body weight support treadmill training (BWSTT). Treatments currently being researched include the use of implantable cells and biomaterials. Our study investigated the changes in locomotive gait and range of motion via a combinational treatment using a bioengineered scaffold [poly (N-isopropyl acrylamide) polyethylene glycol (PNIPAAm-g-PEG) with BDNF and NT-3] and rehabilitation training using BWSTT in a clinically relevant contusion SCI animal model. Five different groups of animals (Sham, Injury, BWSTT, Implant, and Combinational) were tested on a treadmill …
Thermal Fluid Models Of A Hydrogel Delivery System For Pancreatic Cancer Treatment, Nesrine Bouhrira
Thermal Fluid Models Of A Hydrogel Delivery System For Pancreatic Cancer Treatment, Nesrine Bouhrira
Theses and Dissertations
Pancreatic cancer is one of the most devastating cancers with low survival rates. This disease is difficult to detect due to the pancreas's location deep within the body. Therefore, diagnoses are often made in the later stages, making treatment options more limited and difficult. It has been hypothesized that direct injection into the tumor would enhance drug effectivenes. Therefore, we examined the use of endoscopic ultrasound (EUS) combined with a fine needle injection to deliver a drug-eluding thermosensitive hydrogel directly into the tumor. Unfortunately normal body temperatures surrounding the EUS can warm the hydrogel drug combination beyond its phase transition …