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Full-Text Articles in Biomedical Engineering and Bioengineering
Decellularized Bovine Nucleus Pulposus As A Biomimetic Scaffold For Intervertebral Disc Regeneration, Christopher Fernandez
Decellularized Bovine Nucleus Pulposus As A Biomimetic Scaffold For Intervertebral Disc Regeneration, Christopher Fernandez
All Theses
Low back pain (LBP) is a significant burden with a lifetime prevalence of 84% and estimated expenditures of $85.9 billion.[1,2] Although LBP is multifactorial; it has been shown that LBP can originate from degenerating intervertebral discs (IVDs); a process which initiates in the nucleus pulposus (NP); a hydrated tissue primarily composed of type 2 collagen and proteoglycan. Current therapies for IVD degeneration (IDD) are palliative and merely delay surgical management. While these procedures may relieve pain temporarily, they fail to address the underlying cause of degeneration and make no attempt to regenerate the effected tissue. Additional concerns with the use …
Characterization Of Human Muscle Extracellular Matrix, Lauren Klaire Wilson
Characterization Of Human Muscle Extracellular Matrix, Lauren Klaire Wilson
Graduate Theses and Dissertations
The performance of extracellular matrix (ECM) biological scaffolds for the treatment of volumetric muscle loss (VML) has shown promising results with regenerating native muscle in animal models and human patients. However, the limitations of these scaffolds include non-specific characteristics based on the original parameters of the muscle that is lost and this is why our group chose to characterize human skeletal ECM. By understanding the characteristics of the native human skeletal ECM, more desired queues for the biological scaffolds being used to treat VML can be provided. Upper limb and lower limb skeletal muscles were commercially obtained, decellularized using common …