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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

2014

Theses and Dissertations--Biomedical Engineering

Bone graft substitute

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Full-Text Articles in Biomedical Engineering and Bioengineering

Development Of A Moldable Composite Bone Graft Substitute Releasing Antibacterial And Osteogenic Drugs, Matthew E. Brown Jan 2014

Development Of A Moldable Composite Bone Graft Substitute Releasing Antibacterial And Osteogenic Drugs, Matthew E. Brown

Theses and Dissertations--Biomedical Engineering

Large infected bone defects (IBD) are very complicated to treat due to their high variability; they often require multiple procedures. Bone autografts are the gold standard for treatment but have several drawbacks, such as a need for a second surgery site, limited grafting material, and donor site morbidity. The objective of this research was to develop a moldable synthetic bone grafting material capable of releasing both antimicrobial and osteogenic drugs over a clinically relevant time course for the treatment of IBDs. Current treatment methods for large IBDs require two separate procedures to treat the bone defect and the infection.

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