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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

2014

Theses and Dissertations--Biomedical Engineering

Biomechanics and Biotransport

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Full-Text Articles in Biomedical Engineering and Bioengineering

Relationships Of Long-Term Bisphosphonate Treatment With Measures Of Bone Microarchitecture And Mechanical Competence, Jonathan Joseph Ward Jan 2014

Relationships Of Long-Term Bisphosphonate Treatment With Measures Of Bone Microarchitecture And Mechanical Competence, Jonathan Joseph Ward

Theses and Dissertations--Biomedical Engineering

Oral bisphosphonate drug therapy is a common and effective treatment for osteoporosis. Little is known about the long-term effects of bisphosphonates on bone quality. This study examined the structural and mechanical properties of trabecular bone following 0-16 years of bisphosphonate treatment. Fifty-three iliac crest bone samples of Caucasian women diagnosed with low turnover osteoporosis were identified from the Kentucky Bone Registry. Forty-five were treated with oral bisphosphonates for 1 to 16 years while eight were treatment naive. A section of trabecular bone was chosen from a micro-computed tomography (Scanco ┬ÁCT 40) scan of each sample for a uniaxial linearly elastic ...