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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

2014

Doctoral Dissertations

Composite

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Full-Text Articles in Biomedical Engineering and Bioengineering

Engineering Bacterial Cellulose Scaffold And Its Biomimetic Composites For Bone And Cartilage Tissue Regeneration, Pelagie Marlene Favi May 2014

Engineering Bacterial Cellulose Scaffold And Its Biomimetic Composites For Bone And Cartilage Tissue Regeneration, Pelagie Marlene Favi

Doctoral Dissertations

A very promising approach to quickly and safely restore normal function to extensively damages and diseases bone and cartilage tissues is the regeneration of these injured tissues using an engineered support scaffold. This dissertation research focuses on the development and evaluation of native bacterial cellulose (BC) and chemically modified BCs as potential biomaterials for bone and cartilage regeneration using equine-derived bone marrow mesenchymal stem cells (EqMSCs).

The ability of native BC scaffold to maintain cell proliferation, viability, and in vitro differentiation of the seeded EqMSCs for application in bone and cartilage tissue engineering was studied. BC morphology was characterized using ...