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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Unlocking The Secrets Of Multi-Flagellated Propulsion, Stefan Oma Nwandu-Vincent Dec 2014

Unlocking The Secrets Of Multi-Flagellated Propulsion, Stefan Oma Nwandu-Vincent

Doctoral Dissertations

In this work, unique high-speed imaging platforms and an array of theoretical analysis methods are used to thoroughly investigate eukaryotic multi-flagellated propulsion using Tritrichomonas foetus as a test case. Through experimental observations through our imaging system with superior resolution and capture rate exceeding that of previous studies, it was discovered for the first time that the T. foetus employs a strategy similar to that of the “run and tumble” strategies found in bacteria and Chlamydomonas; it has two distinct flagellar beating patterns that result in two different body swimming motions, linear and turning swimming.

These two flagella patterns were ...


Single Cell Biophysics: Applications In Cardiomyocyte Mechanobiology And Stem Cell Mechanotransduction, Benjamin Edward Reese Dec 2014

Single Cell Biophysics: Applications In Cardiomyocyte Mechanobiology And Stem Cell Mechanotransduction, Benjamin Edward Reese

Doctoral Dissertations

While a great deal of work has been done to analyze cardiac dynamics and mechanics at the organ and tissue levels, there remains much less data regarding these metrics at the single cell level. Additionally, as fields such as regenerative medicine and tissue engineering are beginning to demonstrate greater therapeutic potential, the study and influence of stem cell mechanics on differentiation has become a major area of interest. For these reasons, along with the continued advancement of molecular techniques and assays, there is a growing need to develop functional assays that can integrate and bridge the findings from multiple length ...


Engineering Bacterial Cellulose Scaffold And Its Biomimetic Composites For Bone And Cartilage Tissue Regeneration, Pelagie Marlene Favi May 2014

Engineering Bacterial Cellulose Scaffold And Its Biomimetic Composites For Bone And Cartilage Tissue Regeneration, Pelagie Marlene Favi

Doctoral Dissertations

A very promising approach to quickly and safely restore normal function to extensively damages and diseases bone and cartilage tissues is the regeneration of these injured tissues using an engineered support scaffold. This dissertation research focuses on the development and evaluation of native bacterial cellulose (BC) and chemically modified BCs as potential biomaterials for bone and cartilage regeneration using equine-derived bone marrow mesenchymal stem cells (EqMSCs).

The ability of native BC scaffold to maintain cell proliferation, viability, and in vitro differentiation of the seeded EqMSCs for application in bone and cartilage tissue engineering was studied. BC morphology was characterized using ...


Dynamic Complexity And Causality Analysis Of Scalp Eeg For Detection Of Cognitive Deficits, Joseph Curtis Mcbride May 2014

Dynamic Complexity And Causality Analysis Of Scalp Eeg For Detection Of Cognitive Deficits, Joseph Curtis Mcbride

Doctoral Dissertations

This dissertation explores the potential of scalp electroencephalography (EEG) for the detection and evaluation of neurological deficits due to moderate/severe traumatic brain injury (TBI), mild cognitive impairment (MCI), and early Alzheimer’s disease (AD). Neurological disorders often cannot be accurately diagnosed without the use of advanced imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Non-quantitative task-based examinations are also used. None of these techniques, however, are typically performed in the primary care setting. Furthermore, the time and expense involved often deters physicians from performing them, leading to potential worse prognoses for ...


Dynamic Simulations And Data Mining Of Single-Leg Jump Landing: Implications For Anterior Cruciate Ligament Injury Prevention, Kristin Denise Morgan May 2014

Dynamic Simulations And Data Mining Of Single-Leg Jump Landing: Implications For Anterior Cruciate Ligament Injury Prevention, Kristin Denise Morgan

Doctoral Dissertations

It is estimated that 400,000 anterior cruciate ligament (ACL) injuries occur in the United States each year with the cost of ACL reconstruction surgery and rehabilitation exceeding $1 billion annually. The majority of ACL injuries are non-contact injuries occurring during cutting and jump landing movements. Because the majority of the injuries are non-contact injuries there is the potential to develop programs to reduce the risk of injury. Given our understanding of the joint kinematics and kinetics that place an individual at high risk for ACL, researchers have developed neuromuscular training programs that focus on improving muscle function in order ...


Modeling, Analysis, And Control Of A Mobile Robot For In Vivo Fluoroscopy Of Human Joints During Natural Movements, Matthew A. Young May 2014

Modeling, Analysis, And Control Of A Mobile Robot For In Vivo Fluoroscopy Of Human Joints During Natural Movements, Matthew A. Young

Doctoral Dissertations

In this dissertation, the modeling, analysis and control of a multi-degree of freedom (mdof) robotic fluoroscope was investigated. A prototype robotic fluoroscope exists, and consists of a 3 dof mobile platform with two 2 dof Cartesian manipulators mounted symmetrically on opposite sides of the platform. One Cartesian manipulator positions the x-ray generator and the other Cartesian manipulator positions the x-ray imaging device. The robotic fluoroscope is used to x-ray skeletal joints of interest of human subjects performing natural movement activities. In order to collect the data, the Cartesian manipulators must keep the x-ray generation and imaging devices accurately aligned while ...