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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

2014

Bioengineering Senior Theses

Bioengineering; Metastasis; Cell Migration; Cancer; Alginate; Drug Testing; Platform

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Engineering An In Vitro Metastasis Platform, Justus Carlisle, Mark-Phillip Pebworth Jun 2014

Engineering An In Vitro Metastasis Platform, Justus Carlisle, Mark-Phillip Pebworth

Bioengineering Senior Theses

Although metastasis is the primary cause of cancer deaths and results in 90% of all cancer fatalities currently, all attempts to discover anti-metastatic drugs have failed. Many of the traditional methods of studying cell migration, using two-dimensional (2D) platforms, only study two-dimensional migration, which is fundamentally different and more multifaceted than the three-dimensional migration that occurs in vivo. To more accurately capture this in vivo variation, we developed a two-and-a-half-dimensional (2.5D) cell culture platform to better study three-dimensional (3D) migration. This platform consists of a layer of alginate on top of a monolayer of cells grown on tissue culture ...