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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Early Targeting Of Knee Osteoarthritis : Validation Of Computational Methods, Tyler Joseph Stockman Aug 2014

Early Targeting Of Knee Osteoarthritis : Validation Of Computational Methods, Tyler Joseph Stockman

Theses and Dissertations

Osteoarthritis (OA) is the most common type of arthritis, a disease in which inflammation and stiffness of the joints occur. This debilitating disease of the joints currently reigns as the most prevalent among the world's populations. Of particular interest to our group is the study of the biomechanical factors relating to knee OA. Studies have shown that knee OA is related to multiple biomechanical factors, all of which are complexly interrelated. These factors have been seen to produce varied effects on the structures of the knee. This work examines validation of a computational model implementing discrete element analysis, and ...


Design And Application Of Methods For Curating Genetic Variation Databases, Sean Stephen Ephraim Jul 2014

Design And Application Of Methods For Curating Genetic Variation Databases, Sean Stephen Ephraim

Theses and Dissertations

Cordova (Curated Online Reference Database Of Variation Annotations) is an out-of-the-box solution for building and maintaining an online database of genetic variations integrated with population study information and pathogenicity prediction results from popular algorithms. Our primary motivation for developing this system is to aid researchers and clinician-scientists in determining the clinical significance of genetic variations. To achieve this goal, Cordova provides an interface to review and manually or computationally curate genetic variation data as well as share it for clinical diagnostics and the advancement of research.


Preterm Birth: Prediction, Prevention, Care, Brandon Wesley Alleman May 2014

Preterm Birth: Prediction, Prevention, Care, Brandon Wesley Alleman

Theses and Dissertations

Preterm birth (PTB) is defined as birth before 37 weeks gestational age. PTB is a common outcome and one that may be increasing in prevalence with serious individual and public health implications both immediately and long term. While PTB is a pregnancy specific outcome it is more appropriately viewed as the culmination of risk factors present both before pregnancy and possibly in past generations. This thesis attempts to review the implications, risk factors and current prevention strategies directed at PTB while placing it in an intergenerational and life cycle context. Three novel investigations are presented and their consequences are discussed ...