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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

2014

University of Iowa

Diffusion tensor imaging

Articles 1 - 1 of 1

Full-Text Articles in Biomedical Engineering and Bioengineering

Development Of Image Processing Tools And Procedures For Analyzing Multi-Site Longitudinal Diffusion-Weighted Imaging Studies, Joy Tamiko Matsui May 2014

Development Of Image Processing Tools And Procedures For Analyzing Multi-Site Longitudinal Diffusion-Weighted Imaging Studies, Joy Tamiko Matsui

Theses and Dissertations

The logistical complexities of performing multi-site longitudinal diffusion-weighted imaging (DWI) studies requires careful construction of analysis tools and procedures. Proposed clinical trials for therapies in neurodegenerative disease are known to re- quire several hundred subjects, thus mandating multiple site participation to obtain sufficient sample sizes. DWI is an important tool for monitoring diffusivity properties of white matter (WM) in disease progression. The multi-site nature of clinical trials requires new strategies in DWI processing and analysis to reliably measure longitudi- nal WM changes. This work describes the process of developing and validating robust analysis methodologies to process multi-site DWI data in ...