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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

2014

University of Iowa

4DCT

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Full-Text Articles in Biomedical Engineering and Bioengineering

The Dosimetric Impacts Of Gated Radiation Therapy And 4d Dose Calculation In Lung Cancer Patients, Ouided Rouabhi Dec 2014

The Dosimetric Impacts Of Gated Radiation Therapy And 4d Dose Calculation In Lung Cancer Patients, Ouided Rouabhi

Theses and Dissertations

With the introduction of four dimensional-computed tomography (4DCT), treatment centers are now better able to account for respiration-induced uncertainty in radiation therapy treatment planning for lung cancer. We examined two practices in which 4DCT is used in radiotherapy. Our first study investigated the dosimetric uncertainty in four-dimensional (4D) dose calculation using three temporal probability distributions: 1) uniform distribution, 2) sinusoidal distribution, and 3) patient-specific distribution derived from the respiratory trace. Four-dimensional dose was evaluated in nine lung cancer patients. First, dose was computed for each of 10 binned CTs using 4DCT and deformable image registration. Next, the 10 deformed doses ...